Bart Staels

Research interests

Publications

• PPAR control of metabolism and cardiovascular functions

  Nature Reviews Cardiology · 2021 · 10.1038/s41569-021-00569-6

• Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

  European Heart Journal · 2021 · https://doi.org/10.1093/eurheartj/ehab551

• Molecular Actions of PPARα in Lipid Metabolism and Inflammation

  Endocrine Reviews · 2018 · 10.1210/er.2018-00064

• Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

  Gastroenterology · 2017 · 10.1053/j.gastro.2017.01.055

• PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

  Nature Reviews Endocrinology · 2016 · 10.1038/nrendo.2016.135

• Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening

  Gastroenterology · 2016 · https://doi.org/10.1053/j.gastro.2016.01.038

• Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

  Nature Medicine · 2015 · 10.1038/nm.3828

• Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

  Journal of Hepatology · 2014 · https://doi.org/10.1016/j.jhep.2014.10.039

• Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease

  Atherosclerosis · 2013 · https://doi.org/10.1016/j.atherosclerosis.2013.11.043

• Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

  Physiological Reviews · 2009 · https://doi.org/10.1152/physrev.00010.2008

• PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties

  Cell Metabolism · 2007 · https://doi.org/10.1016/j.cmet.2007.06.010

• International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

  Pharmacological Reviews · 2006 · 10.1124/pr.58.4.5

• Peroxisome proliferator-activated receptors in inflammation control

  Journal of Endocrinology · 2001 · 10.1677/joe.0.1690453

• PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway

  Nature Medicine · 2001 · 10.1038/83348

• Peroxisome proliferator-activated receptors (PPARs): Nuclear receptors at the crossroads between lipid metabolism and inflammation

  Inflammation Research · 2000 · 10.1007/s000110050622

• Protective Role of Interleukin-10 in Atherosclerosis

  Circulation Research · 1999 · 10.1161/01.res.85.8.e17

• Peroxisome Proliferator-activated Receptor α Negatively Regulates the Vascular Inflammatory Gene Response by Negative Cross-talk with Transcription Factors NF-κB and AP-1

  Journal of Biological Chemistry · 1999 · 10.1074/jbc.274.45.32048

• Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

  Circulation · 1998 · https://doi.org/10.1161/01.cir.98.19.2088

• Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators

  Nature · 1998 · 10.1038/31701

• Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

  Journal of Biological Chemistry · 1998 · 10.1074/jbc.273.40.25573

• The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene

  Journal of Biological Chemistry · 1997 · 10.1074/jbc.272.30.18779

• Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients

  Diabetes · 1997 · 10.2337/diab.46.8.1319

• The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

  Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1996 · 10.1016/0005-2760(96)00066-5

• Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

  Journal of Lipid Research · 1996 · https://doi.org/10.1016/s0022-2275(20)42003-6

• PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

  The EMBO Journal · 1996 · 10.1002/j.1460-2075.1996.tb00918.x

• Transient increase in obese gene expression after food intake or insulin administration

  Nature · 1995 · 10.1038/377527a0

Current projects

No projects listed.