Carel W. le Roux

Research interests

Publications

• Definition and diagnostic criteria of clinical obesity

  The Lancet Diabetes & Endocrinology · 2025 · https://doi.org/10.1016/s2213-8587(24)00316-4

• Tirzepatide as Compared with Semaglutide for the Treatment of Obesity

  New England Journal of Medicine · 2025 · 10.1056/nejmoa2416394

• Obesity in adults

  The Lancet · 2024 · 10.1016/s0140-6736(24)01210-8

• Tirzepatide for Obesity Treatment and Diabetes Prevention

  New England Journal of Medicine · 2024 · 10.1056/nejmoa2410819

• Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial

  The Lancet · 2023 · https://doi.org/10.1016/s0140-6736(23)01200-x

• Obesity and cardiovascular disease: mechanistic insights and management strategies. A joint position paper by the World Heart Federation and World Obesity Federation

  European Journal of Preventive Cardiology · 2022 · 10.1093/eurjpc/zwac187

• Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation

  The Lancet · 2021 · 10.1016/s0140-6736(21)01919-x

• Consensus Report: Definition and Interpretation of Remission in Type 2 Diabetes

  Diabetes Care · 2021 · 10.2337/dci21-0034

• Joint international consensus statement for ending stigma of obesity

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0803-x

• Morbidity and mortality associated with obesity

  Annals of Translational Medicine · 2017 · https://doi.org/10.21037/atm.2017.03.107

• 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial

  The Lancet · 2017 · https://doi.org/10.1016/s0140-6736(17)30069-7

• Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

  Diabetes Care · 2016 · 10.2337/dc16-0236

• Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation

  Cell Metabolism · 2015 · 10.1016/j.cmet.2015.07.009

• A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

  New England Journal of Medicine · 2015 · https://doi.org/10.1056/nejmoa1411892

• Mechanisms underlying weight loss after bariatric surgery

  Nature Reviews Gastroenterology & Hepatology · 2013 · 10.1038/nrgastro.2013.119

• The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

  Endocrinology · 2012 · 10.1210/en.2011-2145

• Metabolic surgery profoundly influences gut microbial–host metabolic cross-talk

  Gut · 2011 · 10.1136/gut.2010.234708

• A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis

  Clinical Gastroenterology and Hepatology · 2009 · 10.1016/j.cgh.2009.04.024

• Gut Hormones as Mediators of Appetite and Weight Loss After Roux-en-Y Gastric Bypass

  Annals of Surgery · 2007 · 10.1097/sla.0b013e3180caa3e3

• Critical role for peptide YY in protein-mediated satiation and body-weight regulation

  Cell Metabolism · 2006 · 10.1016/j.cmet.2006.08.001

• Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters

  Annals of Surgery · 2005 · 10.1097/01.sla.0000183349.16877.84

• Attenuated Peptide YY Release in Obese Subjects Is Associated with Reduced Satiety

  Endocrinology · 2005 · 10.1210/en.2005-0972

• Oxyntomodulin Suppresses Appetite and Reduces Food Intake in Humans

  The Journal of Clinical Endocrinology & Metabolism · 2003 · 10.1210/jc.2003-030421

• Pancreatic Polypeptide Reduces Appetite and Food Intake in Humans

  The Journal of Clinical Endocrinology & Metabolism · 2003 · 10.1210/jc.2003-030630

• Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36

  New England Journal of Medicine · 2003 · https://doi.org/10.1056/nejmoa030204

Current projects

No projects listed.