Xia Yang

Research interests

Publications

• Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-24232-3

• Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

  Diabetes · 2019 · https://doi.org/10.2337/db18-0927

• Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

  eLife · 2019 · https://doi.org/10.7554/elife.49501

• Integration of Multi-omics Data from Mouse Diversity Panel Highlights Mitochondrial Dysfunction in Non-alcoholic Fatty Liver Disease

  Cell Systems · 2018 · https://doi.org/10.1016/j.cels.2017.12.006

• Co-regulatory networks of human serum proteins link genetics to disease

  Science · 2018 · https://doi.org/10.1126/science.aaq1327

• Single cell molecular alterations reveal target cells and pathways of concussive brain injury

  Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-06222-0

• Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue

  Molecular & Cellular Proteomics · 2017 · https://doi.org/10.1074/mcp.m116.065524

• Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis

  Cell Metabolism · 2016 · https://doi.org/10.1016/j.cmet.2016.11.001

• Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

  Molecular Systems Biology · 2014 · https://doi.org/10.15252/msb.20145304

• Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway

  Neuron · 2014 · https://doi.org/10.1016/j.neuron.2014.02.041

• Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

  PLoS Genetics · 2014 · https://doi.org/10.1371/journal.pgen.1004502

• Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

  The American Journal of Human Genetics · 2013 · https://doi.org/10.1016/j.ajhg.2013.03.022

• Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

  Diabetes · 2013 · https://doi.org/10.2337/db13-0949

• A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease

  Arteriosclerosis Thrombosis and Vascular Biology · 2013 · https://doi.org/10.1161/atvbaha.112.300112

• Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

  Neuron · 2012 · https://doi.org/10.1016/j.neuron.2012.05.024

• Liver and Adipose Expression Associated SNPs Are Enriched for Association to Type 2 Diabetes

  PLoS Genetics · 2010 · https://doi.org/10.1371/journal.pgen.1000932

• Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver

  Genome Research · 2010 · https://doi.org/10.1101/gr.103341.109

• Integrating Pathway Analysis and Genetics of Gene Expression for Genome-wide Association Studies

  The American Journal of Human Genetics · 2010 · https://doi.org/10.1016/j.ajhg.2010.02.020

• Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.325

• Variations in DNA elucidate molecular networks that cause disease

  Nature · 2008 · https://doi.org/10.1038/nature06757

• Mapping the Genetic Architecture of Gene Expression in Human Liver

  PLoS Biology · 2008 · https://doi.org/10.1371/journal.pbio.0060107

• Dosage compensation is less effective in birds than in mammals

  Journal of Biology · 2007 · https://doi.org/10.1186/jbiol53

• Tissue-specific expression and regulation of sexually dimorphic genes in mice

  Genome Research · 2006 · https://doi.org/10.1101/gr.5217506

• An integrative genomics approach to infer causal associations between gene expression and disease

  Nature Genetics · 2005 · https://doi.org/10.1038/ng1589

Current projects

No projects listed.