Franco Locatelli

Research interests

Publications

• Exagamglogene Autotemcel for Severe Sickle Cell Disease

  New England Journal of Medicine · 2024 · 10.1056/nejmoa2309676

• GD2-CART01 for Relapsed or Refractory High-Risk Neuroblastoma

  New England Journal of Medicine · 2023 · 10.1056/nejmoa2210859

• Ruxolitinib for Glucocorticoid-Refractory Chronic Graft-versus-Host Disease

  New England Journal of Medicine · 2021 · 10.1056/nejmoa2033122

• Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis

  New England Journal of Medicine · 2020 · 10.1056/nejmoa1911326

• Coronavirus infections: Epidemiological, clinical and immunological features and hypotheses

  Cell Stress · 2020 · 10.15698/cst2020.04.216

• CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2031054

• Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study

  The Lancet Respiratory Medicine · 2020 · https://doi.org/10.1016/s2213-2600(20)30370-2

• Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

  Cell Death and Differentiation · 2019 · 10.1038/s41418-019-0292-y

• Killer Ig-Like Receptors (KIRs): Their Role in NK Cell Modulation and Developments Leading to Their Clinical Exploitation

  Frontiers in Immunology · 2019 · 10.3389/fimmu.2019.01179

• Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia

  Journal of Clinical Oncology · 2016 · 10.1200/jco.2016.67.3301

• International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium

  Transplantation and Cellular Therapy · 2015 · https://doi.org/10.1016/j.bbmt.2015.09.001

• Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents

  Blood · 2015 · 10.1182/blood-2015-09-669937

• Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia

  Journal of Clinical Oncology · 2015 · 10.1200/jco.2015.62.8289

• HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

  Blood · 2014 · 10.1182/blood-2014-03-563817

• Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

  Gut · 2011 · 10.1136/gut.2010.214841

• Late MRD response determines relapse risk overall and in subsets of childhood T-cell ALL: results of the AIEOP-BFM-ALL 2000 study

  Blood · 2011 · 10.1182/blood-2011-03-338707

• Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study

  Blood · 2010 · https://doi.org/10.1182/blood-2009-10-248146

• Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

  Nature Genetics · 2010 · 10.1038/ng.641

• Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study

  The Lancet · 2008 · https://doi.org/10.1016/s0140-6736(08)60690-x

• Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

  Blood · 2008 · 10.1182/blood-2008-06-164103

• Cotransplantation of ex vivo–expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation

  Blood · 2007 · 10.1182/blood-2007-04-087056

• Human Bone Marrow–Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-term In vitro Culture and Do Not Exhibit Telomere Maintenance Mechanisms

  Cancer Research · 2007 · 10.1158/0008-5472.can-06-4690

• Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype.

  PubMed · 2005

• Factors associated with outcomes of unrelated cord blood transplant: Guidelines for donor choice

  Experimental Hematology · 2004 · 10.1016/j.exphem.2004.01.002

• Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)

  PubMed · 1997 · 10.1182/blood.v89.10.3534

Current projects

No projects listed.