Francesco Cecconi

Research interests

Publications

• Autophagy in major human diseases

  The EMBO Journal · 2021 · https://doi.org/10.15252/embj.2021108863

• Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

  Cell Death and Differentiation · 2019 · 10.1038/s41418-019-0292-y

• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  Cell Death and Differentiation · 2018 · https://doi.org/10.1038/s41418-017-0012-4

• Molecular definitions of autophagy and related processes

  The EMBO Journal · 2017 · https://doi.org/10.15252/embj.201796697

• Autophagy in malignant transformation and cancer progression

  The EMBO Journal · 2015 · https://doi.org/10.15252/embj.201490784

• AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2014.139

• Oxidative stress and autophagy: the clash between damage and metabolic needs

  Cell Death and Differentiation · 2014 · https://doi.org/10.1038/cdd.2014.150

• Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

  Cell Death and Differentiation · 2014 · 10.1038/cdd.2014.137

• mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

  Nature Cell Biology · 2013 · 10.1038/ncb2708

• The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

  The Journal of Cell Biology · 2010 · 10.1083/jcb.201002100

• Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease

  Nature Neuroscience · 2010 · 10.1038/nn.2709

• Inflammation Triggers Synaptic Alteration and Degeneration in Experimental Autoimmune Encephalomyelitis

  Journal of Neuroscience · 2009 · 10.1523/jneurosci.5804-08.2009

• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

  Journal of Clinical Investigation · 2009 · 10.1172/jci37948

• Neuronal caspase-3 signaling: not only cell death

  Cell Death and Differentiation · 2009 · 10.1038/cdd.2009.180

• Regulation of autophagy by cytoplasmic p53

  Nature Cell Biology · 2008 · 10.1038/ncb1730

• The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

  Developmental Cell · 2008 · 10.1016/j.devcel.2008.08.012

• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

  Autophagy · 2008 · 10.4161/auto.5338

• Ambra1 regulates autophagy and development of the nervous system

  Nature · 2007 · 10.1038/nature05925

• Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak‐mediated permeabilization

  The EMBO Journal · 2003 · 10.1093/emboj/cdg423

• Apoptosis-inducing factor (AIF): key to the conserved caspase-independent pathways of cell death?

  Journal of Cell Science · 2002 · 10.1242/jcs.00210

• Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

  Nature · 2002 · 10.1038/nature01101

• Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

  The Journal of Cell Biology · 2002 · 10.1083/jcb.200202130

• Glial cells generate neurons: the role of the transcription factor Pax6

  Nature Neuroscience · 2002 · 10.1038/nn828

• Apaf-1 is a transcriptional target for E2F and p53

  Nature Cell Biology · 2001 · 10.1038/35078527

• Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

  Cell · 1998 · 10.1016/s0092-8674(00)81732-8

Current projects

No projects listed.