Jay D. Keasling

Research interests

Publications

• A microbial supply chain for production of the anti-cancer drug vinblastine

  Nature · 2022 · 10.1038/s41586-022-05157-3

• Complete biosynthesis of cannabinoids and their unnatural analogues in yeast

  Nature · 2019 · 10.1038/s41586-019-0978-9

• Engineering Cellular Metabolism

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.02.004

• Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

  Nature Reviews Microbiology · 2014 · 10.1038/nrmicro3240

• High-level semi-synthetic production of the potent antimalarial artemisinin

  Nature · 2013 · https://doi.org/10.1038/nature12051

• Precise and reliable gene expression via standard transcription and translation initiation elements

  Nature Methods · 2013 · 10.1038/nmeth.2404

• Engineering dynamic pathway regulation using stress-response promoters

  Nature Biotechnology · 2013 · 10.1038/nbt.2689

• Synthetic biology and the development of tools for metabolic engineering

  Metabolic Engineering · 2012 · 10.1016/j.ymben.2012.01.004

• Microbial engineering for the production of advanced biofuels

  Nature · 2012 · 10.1038/nature11478

• Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

  Nature Biotechnology · 2012 · 10.1038/nbt.2149

• Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1110740109

• BglBrick vectors and datasheets: A synthetic biology platform for gene expression

  Journal of Biological Engineering · 2011 · 10.1186/1754-1611-5-12

• Engineering microbial biofuel tolerance and export using efflux pumps

  Molecular Systems Biology · 2011 · 10.1038/msb.2011.21

• Identification and microbial production of a terpene-based advanced biofuel

  Nature Communications · 2011 · 10.1038/ncomms1494

• Manufacturing Molecules Through Metabolic Engineering

  Science · 2010 · 10.1126/science.1193990

• BglBricks: A flexible standard for biological part assembly

  Journal of Biological Engineering · 2010 · 10.1186/1754-1611-4-1

• Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

  Nature · 2010 · https://doi.org/10.1038/nature08721

• Biosynthesis of Plant Isoprenoids: Perspectives for Microbial Engineering

  Annual Review of Plant Biology · 2009 · 10.1146/annurev.arplant.043008.091955

• Synthetic protein scaffolds provide modular control over metabolic flux

  Nature Biotechnology · 2009 · 10.1038/nbt.1557

• Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol

  Microbial Cell Factories · 2008 · 10.1186/1475-2859-7-36

• Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli

  Metabolic Engineering · 2006 · 10.1016/j.ymben.2006.11.002

• Designed divergent evolution of enzyme function

  Nature · 2006 · 10.1038/nature04607

• Combinatorial engineering of intergenic regions in operons tunes expression of multiple genes

  Nature Biotechnology · 2006 · 10.1038/nbt1226

• Production of the antimalarial drug precursor artemisinic acid in engineered yeast

  Nature · 2006 · https://doi.org/10.1038/nature04640

• Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

  Nature Biotechnology · 2003 · https://doi.org/10.1038/nbt833

Current projects

No projects listed.