James S. Fraser

Researcher Next ID · RN-019460

Researcher · Biochemistry, Genetics and Molecular Biology

San Francisco, Argentina

Not currently recruitingFunding unknown

Research interests

Biochemistry, Genetics and Molecular Biology

Materials Science

Computer Science

Protein Structure and Dynamics

Enzyme Structure and Function

RNA and protein synthesis mechanisms

PI3K/AKT/mTOR signaling in cancer

Computational Drug Discovery Methods

Large language models generate functional protein sequences across diverse families
Nature Biotechnology · 2023 · https://doi.org/10.1038/s41587-022-01618-2
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
Science Advances · 2021 · https://doi.org/10.1126/sciadv.abf8711
A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing
bioRxiv (Cold Spring Harbor Laboratory) · 2020 · https://doi.org/10.1101/2020.03.22.002386
Promoting transparency and reproducibility in enhanced molecular simulations
Nature Methods · 2019 · https://doi.org/10.1038/s41592-019-0506-8
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
eLife · 2018 · https://doi.org/10.7554/elife.36307
Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta
eLife · 2016 · https://doi.org/10.7554/elife.17219
EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
Nature Methods · 2015 · https://doi.org/10.1038/nmeth.3541
Accessing protein conformational ensembles using room-temperature X-ray crystallography
Proceedings of the National Academy of Sciences · 2011 · https://doi.org/10.1073/pnas.1111325108

No projects listed.