Eleanor Wheeler

Research interests

Publications

• Mapping the proteo-genomic convergence of human diseases

  Science · 2021 · https://doi.org/10.1126/science.abj1541

• Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.10.004

• Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.03.044

• Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

  PLoS Medicine · 2017 · https://doi.org/10.1371/journal.pmed.1002383

• The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.10.042

• Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

  Nature Genetics · 2016 · https://doi.org/10.1038/ng.3714

• Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study

  PLoS Medicine · 2014 · https://doi.org/10.1371/journal.pmed.1001647

• Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2607

• Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2606

• Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2385

• The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

  PLoS Genetics · 2012 · https://doi.org/10.1371/journal.pgen.1002793

• A genome-wide association meta-analysis identifies new childhood obesity loci

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2247

• Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

  Diabetes · 2011 · https://doi.org/10.2337/db11-0415

• Hundreds of variants clustered in genomic loci and biological pathways affect human height

  Nature · 2010 · https://doi.org/10.1038/nature09410

• Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

  Diabetes · 2010 · https://doi.org/10.2337/db10-0502

• Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.686

• Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

  Arteriosclerosis Thrombosis and Vascular Biology · 2010 · https://doi.org/10.1161/atvbaha.109.201020

• Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

  Nature Genetics · 2010 · 10.1038/ng.685

• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  Nature Genetics · 2010 · 10.1038/ng.520

• Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size

  PLoS Genetics · 2009 · https://doi.org/10.1371/journal.pgen.1000445

• Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

  Nature Genetics · 2008 · https://doi.org/10.1038/ng.287

• LDL-cholesterol concentrations: a genome-wide association study

  The Lancet · 2008 · https://doi.org/10.1016/s0140-6736(08)60208-1

• Variants in MTNR1B influence fasting glucose levels

  Nature Genetics · 2008 · 10.1038/ng.290

• Common variants near MC4R are associated with fat mass, weight and risk of obesity

  Nature Genetics · 2008 · 10.1038/ng.140

Current projects

No projects listed.