Masahiro Kanai

Research interests

Publications

• Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference

  Nature Genetics · 2024 · https://doi.org/10.1038/s41588-023-01596-4

• Author Correction: A genomic mutational constraint map using variation in 76,156 human genomes

  Nature · 2024 · 10.1038/s41586-024-07050-7

• A genomic mutational constraint map using variation in 76,156 human genomes

  Nature · 2023 · https://doi.org/10.1038/s41586-023-06045-0

• FinnGen provides genetic insights from a well-phenotyped isolated population

  Nature · 2023 · https://doi.org/10.1038/s41586-022-05473-8

• Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases

  Nature Genetics · 2023 · 10.1038/s41588-023-01443-6

• Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

  Cell Genomics · 2022 · 10.1016/j.xgen.2022.100192

• Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

  Nature Genetics · 2022 · 10.1038/s41588-022-01036-9

• A genome-wide mutational constraint map quantified from variation in 76,156 human genomes

  bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 10.1101/2022.03.20.485034

• FinnGen: Unique genetic insights from combining isolated population and national health register data

  medRxiv · 2022 · 10.1101/2022.03.03.22271360

• The power of genetic diversity in genome-wide association studies of lipids

  Nature · 2021 · https://doi.org/10.1038/s41586-021-04064-3

• Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

  Nature Medicine · 2021 · 10.1038/s41591-021-01549-6

• Genetic analyses identify widespread sex-differential participation bias

  Nature Genetics · 2021 · 10.1038/s41588-021-00846-7

• Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

  Nature Genetics · 2021 · 10.1038/s41588-020-00766-y

• A cross-population atlas of genetic associations for 220 human phenotypes

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00931-x

• A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

  Nature Genetics · 2021 · 10.1038/s41588-021-00935-7

• Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

  Nature Genetics · 2020 · 10.1038/s41588-020-0640-3

• Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

  Cell · 2020 · 10.1016/j.cell.2020.06.045

• The Polygenic and Monogenic Basis of Blood Traits and Diseases

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.008

• Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population

  Nature Genetics · 2019 · 10.1038/s41588-018-0332-4

• Characterizing rare and low-frequency height-associated variants in the Japanese population

  Nature Communications · 2019 · 10.1038/s41467-019-12276-5

• Clinical use of current polygenic risk scores may exacerbate health disparities

  Nature Genetics · 2019 · 10.1038/s41588-019-0379-x

• Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

  Nature Genetics · 2019 · 10.1038/s41588-019-0504-x

• Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

  Nature Genetics · 2018 · 10.1038/s41588-018-0047-6

• Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

  Nature Genetics · 2018 · 10.1038/s41588-018-0058-3

• Genome-wide association study identifies 112 new loci for body mass index in the Japanese population

  Nature Genetics · 2017 · 10.1038/ng.3951

Current projects

No projects listed.