Francisco J. Quintana

Research interests

Publications

• Function and therapeutic value of astrocytes in neurological diseases

  Nature Reviews Drug Discovery · 2022 · 10.1038/s41573-022-00390-x

• Reactive astrocyte nomenclature, definitions, and future directions

  Nature Neuroscience · 2021 · https://doi.org/10.1038/s41593-020-00783-4

• Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation

  Annual Review of Immunology · 2021 · 10.1146/annurev-immunol-093019-110159

• Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes

  Nature · 2021 · 10.1038/s41586-020-03116-4

• Negative feedback control of neuronal activity by microglia

  Nature · 2020 · 10.1038/s41586-020-2777-8

• MAFG-driven astrocytes promote CNS inflammation

  Nature · 2020 · 10.1038/s41586-020-1999-0

• The Role of Astrocytes in CNS Inflammation

  Trends in Immunology · 2020 · 10.1016/j.it.2020.07.007

• Astrocyte Crosstalk in CNS Inflammation

  Neuron · 2020 · 10.1016/j.neuron.2020.08.012

• Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

  Nature Neuroscience · 2019 · 10.1038/s41593-019-0370-y

• The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

  Nature reviews. Immunology · 2019 · https://doi.org/10.1038/s41577-019-0125-8

• Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

  Immunity · 2018 · 10.1016/j.immuni.2017.12.012

• Microglial control of astrocytes in response to microbial metabolites

  Nature · 2018 · 10.1038/s41586-018-0119-x

• Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

  Cell · 2016 · 10.1016/j.cell.2016.05.034

• Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

  Nature Medicine · 2016 · https://doi.org/10.1038/nm.4106

• Alterations of the human gut microbiome in multiple sclerosis

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms12015

• Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

  Nature Medicine · 2015 · 10.1038/nm.3868

• Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

  Immunity · 2014 · 10.1016/j.immuni.2014.03.011

• Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses

  Immunity · 2014 · 10.1016/j.immuni.2014.02.012

• Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

  Nature Medicine · 2014 · 10.1038/nm.3681

• Induction and molecular signature of pathogenic TH17 cells

  Nature Immunology · 2012 · https://doi.org/10.1038/ni.2416

• Oral tolerance

  Immunological Reviews · 2011 · 10.1111/j.1600-065x.2011.01017.x

• Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

  Nature Immunology · 2010 · 10.1038/ni.1915

• An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.1009201107

• The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

  Nature Immunology · 2010 · 10.1038/ni.1912

• Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

  Nature · 2008 · 10.1038/nature06880

Current projects

No projects listed.