George C. Tsokos

Research interests

Publications

• The role of platelets in immune-mediated inflammatory diseases

  Nature reviews. Immunology · 2023 · 10.1038/s41577-023-00834-4

• Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity

  Nature Immunology · 2021 · 10.1038/s41590-021-00993-3

• An Autoimmunogenic and Proinflammatory Profile Defined by the Gut Microbiota of Patients With Untreated Systemic Lupus Erythematosus

  Arthritis & Rheumatology · 2020 · 10.1002/art.41511

• Autoimmunity and organ damage in systemic lupus erythematosus

  Nature Immunology · 2020 · https://doi.org/10.1038/s41590-020-0677-6

• T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy

  Nature Reviews Rheumatology · 2020 · 10.1038/s41584-019-0356-x

• Regulatory T cells in the treatment of disease

  Nature Reviews Drug Discovery · 2018 · 10.1038/nrd.2018.148

• Efficacy and safety of ustekinumab, an IL-12 and IL-23 inhibitor, in patients with active systemic lupus erythematosus: results of a multicentre, double-blind, phase 2, randomised, controlled study

  The Lancet · 2018 · 10.1016/s0140-6736(18)32167-6

• Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus

  Frontiers in Immunology · 2018 · 10.3389/fimmu.2018.01088

• Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective

  Trends in Molecular Medicine · 2017 · 10.1016/j.molmed.2017.05.006

• New insights into the immunopathogenesis of systemic lupus erythematosus

  Nature Reviews Rheumatology · 2016 · https://doi.org/10.1038/nrrheum.2016.186

• T cells in Systemic Lupus Erythematosus

  Current Opinion in Immunology · 2016 · 10.1016/j.coi.2016.09.001

• Phosphatase PP2A is requisite for the function of regulatory T cells

  Nature Immunology · 2016 · 10.1038/ni.3390

• Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

  Annals of the Rheumatic Diseases · 2016 · 10.1136/annrheumdis-2015-208140

• T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity

  Journal of Clinical Investigation · 2015 · 10.1172/jci78087

• CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance

  Journal of Clinical Investigation · 2014 · 10.1172/jci73411

• Systemic Lupus Erythematosus

  New England Journal of Medicine · 2011 · https://doi.org/10.1056/nejmra1100359

• T cells as therapeutic targets in SLE

  Nature Reviews Rheumatology · 2010 · 10.1038/nrrheum.2010.60

• Pathogenesis of human systemic lupus erythematosus: recent advances

  Trends in Molecular Medicine · 2010 · 10.1016/j.molmed.2009.12.005

• The Role of IL-23/IL-17 Axis in Lupus Nephritis

  The Journal of Immunology · 2009 · 10.4049/jimmunol.0900385

• Interleukin-17 and systemic lupus erythematosus: current concepts

  Clinical & Experimental Immunology · 2009 · 10.1111/j.1365-2249.2009.03944.x

• Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

  The Journal of Immunology · 2008 · https://doi.org/10.4049/jimmunol.181.12.8761

• Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

  Journal of Clinical Investigation · 2005 · 10.1172/jci22854

• Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain.

  Journal of Clinical Investigation · 1998 · 10.1172/jci1457

• B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events.

  Journal of Clinical Investigation · 1996 · 10.1172/jci119073

• T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

  The Journal of Immunology · 1989 · 10.4049/jimmunol.143.1.103

Current projects

No projects listed.