Chris Sander

Research interests

Publications

• The reactome pathway knowledgebase 2022

  Nucleic Acids Research · 2021 · https://doi.org/10.1093/nar/gkab1028

• Genomic and Functional Approaches to Understanding Cancer Aneuploidy

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.03.007

• An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.02.052

• Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.07.001

• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.050

• Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

  Cell Reports · 2018 · 10.1016/j.celrep.2018.01.088

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

  Cell · 2018 · 10.1016/j.cell.2018.03.034

• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

  Cell Systems · 2018 · 10.1016/j.cels.2018.03.002

• lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.006

• Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

  Journal of Clinical Investigation · 2016 · 10.1172/jci85271

• Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures

  Genome biology · 2016 · 10.1186/s13059-016-1092-z

• Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

  Science · 2015 · https://doi.org/10.1126/science.aaa1348

• Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

  Cell · 2015 · 10.1016/j.cell.2015.09.033

• Comprehensive molecular characterization of gastric adenocarcinoma

  Nature · 2014 · https://doi.org/10.1038/nature13480

• Comprehensive molecular profiling of lung adenocarcinoma

  Nature · 2014 · 10.1038/nature13385

• Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

  Nature · 2014 · 10.1038/nature13828

• Emerging landscape of oncogenic signatures across human cancers

  Nature Genetics · 2013 · 10.1038/ng.2762

• Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

  Science Signaling · 2013 · https://doi.org/10.1126/scisignal.2004088

• Evaluating cell lines as tumour models by comparison of genomic profiles

  Nature Communications · 2013 · 10.1038/ncomms3126

• The Cancer Genome Atlas Pan-Cancer analysis project

  Nature Genetics · 2013 · https://doi.org/10.1038/ng.2764

• The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

  Cancer Discovery · 2012 · https://doi.org/10.1158/2159-8290.cd-12-0095

• Predicting the functional impact of protein mutations: application to cancer genomics

  Nucleic Acids Research · 2011 · 10.1093/nar/gkr407

• Direct-coupling analysis of residue coevolution captures native contacts across many protein families

  Proceedings of the National Academy of Sciences · 2011 · 10.1073/pnas.1111471108

• Integrative Genomic Profiling of Human Prostate Cancer

  Cancer Cell · 2010 · 10.1016/j.ccr.2010.05.026

• Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites

  Genome biology · 2010 · 10.1186/gb-2010-11-8-r90

• Pathway Commons, a web resource for biological pathway data

  Nucleic Acids Research · 2010 · 10.1093/nar/gkq1039

• The microRNA.org resource: targets and expression

  Nucleic Acids Research · 2007 · 10.1093/nar/gkm995

• Integration of biological networks and gene expression data using Cytoscape

  Nature Protocols · 2007 · 10.1038/nprot.2007.324

• A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

  Cell · 2007 · 10.1016/j.cell.2007.04.040

• Human MicroRNA Targets

  PLoS Biology · 2004 · 10.1371/journal.pbio.0020363

• Identification of Virus-Encoded MicroRNAs

  Science · 2004 · 10.1126/science.1096781

• Global Mapping of the Yeast Genetic Interaction Network

  Science · 2004 · 10.1126/science.1091317

• MicroRNA targets in Drosophila

  Genome biology · 2003 · 10.1186/gb-2003-5-1-r1

• Errors in protein structures

  Nature · 1996 · 10.1038/381272a0

• Prediction of Protein Secondary Structure at Better than 70% Accuracy

  Journal of Molecular Biology · 1993 · 10.1006/jmbi.1993.1413

• Protein Structure Comparison by Alignment of Distance Matrices

  Journal of Molecular Biology · 1993 · 10.1006/jmbi.1993.1489

Current projects

No projects listed.