Matthew G. Vander Heiden

Research interests

Publications

• Cell-programmed nutrient partitioning in the tumour microenvironment

  Nature · 2021 · 10.1038/s41586-021-03442-1

• Metabolomics in cancer research and emerging applications in clinical oncology

  CA A Cancer Journal for Clinicians · 2021 · 10.3322/caac.21670

• Targeting Metabolism for Cancer Therapy

  Cell chemical biology · 2017 · 10.1016/j.chembiol.2017.08.028

• Understanding the Intersections between Metabolism and Cancer Biology

  Cell · 2017 · https://doi.org/10.1016/j.cell.2016.12.039

• Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

  Nature Medicine · 2017 · 10.1038/nm.4407

• Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.01.007

• A roadmap for interpreting 13C metabolite labeling patterns from cells

  Current Opinion in Biotechnology · 2015 · https://doi.org/10.1016/j.copbio.2015.02.003

• Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

  Cancer Research · 2015 · https://doi.org/10.1158/0008-5472.can-14-2211

• Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

  Cell Metabolism · 2015 · https://doi.org/10.1016/j.cmet.2014.12.005

• Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

  Cell · 2015 · 10.1016/j.cell.2015.07.017

• Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

  Nature Medicine · 2014 · 10.1038/nm.3686

• Metabolic targets for cancer therapy

  Nature Reviews Drug Discovery · 2013 · 10.1038/nrd4145

• Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

  Nature · 2013 · https://doi.org/10.1038/nature12138

• Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

  Nature Chemical Biology · 2012 · 10.1038/nchembio.1060

• Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

  Nature · 2011 · 10.1038/nature10602

• Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

  Nature Genetics · 2011 · 10.1038/ng.890

• Targeting cancer metabolism: a therapeutic window opens

  Nature Reviews Drug Discovery · 2011 · 10.1038/nrd3504

• Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

  Science · 2011 · 10.1126/science.1211485

• Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

  Annual Review of Cell and Developmental Biology · 2011 · 10.1146/annurev-cellbio-092910-154237

• Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

  Molecular Cell · 2010 · 10.1016/j.molcel.2010.06.022

• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  Science · 2009 · 10.1126/science.1160809

• Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

  Science Signaling · 2009 · 10.1126/scisignal.2000431

• Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

  Nature · 2009 · 10.1038/nature08617

• The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

  Nature · 2008 · 10.1038/nature06734

• Pyruvate kinase M2 is a phosphotyrosine-binding protein

  Nature · 2008 · 10.1038/nature06667

• Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

  Cell · 1997 · 10.1016/s0092-8674(00)80450-x

Current projects

No projects listed.