Joseph Loscalzo

Research interests

Publications

• Network-based approach to prediction and population-based validation of in silico drug repurposing

  Nature Communications · 2018 · 10.1038/s41467-018-05116-5

• NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

  Antioxidants and Redox Signaling · 2017 · 10.1089/ars.2017.7216

• Genetic Misdiagnoses and the Potential for Health Disparities

  New England Journal of Medicine · 2016 · 10.1056/nejmsa1507092

• Uncovering disease-disease relationships through the incomplete interactome

  Science · 2015 · https://doi.org/10.1126/science.1257601

• Redox Regulation of Mitochondrial Function

  Antioxidants and Redox Signaling · 2011 · 10.1089/ars.2011.4123

• Epigenetic Modifications

  Circulation · 2011 · 10.1161/circulationaha.110.956839

• Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

  PLoS ONE · 2010 · https://doi.org/10.1371/journal.pone.0010693

• Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

  Antioxidants and Redox Signaling · 2010 · 10.1089/ars.2010.3586

• Network medicine: a network-based approach to human disease

  Nature Reviews Genetics · 2010 · https://doi.org/10.1038/nrg2918

• MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

  Cell Metabolism · 2009 · 10.1016/j.cmet.2009.08.015

• Human disease classification in the postgenomic era: A complex systems approach to human pathobiology

  Molecular Systems Biology · 2007 · 10.1038/msb4100163

• Vascular Calcification

  Circulation Research · 2006 · 10.1161/01.res.0000249379.55535.21

• Pulmonary Arterial Hypertension

  New England Journal of Medicine · 2004 · 10.1056/nejmra035488

• Nitric Oxide Insufficiency, Platelet Activation, and Arterial Thrombosis

  Circulation Research · 2001 · 10.1161/hh0801.089861

• Aspirin

  Circulation · 2000 · 10.1161/01.cir.101.10.1206

• Endothelial cells in physiology and in the pathophysiology of vascular disorders.

  PubMed · 1998 · https://doi.org/10.1182/blood.v91.10.3527

• Homocysteine and Atherothrombosis

  New England Journal of Medicine · 1998 · https://doi.org/10.1056/nejm199804093381507

• Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase

  Journal of Biological Chemistry · 1997 · 10.1074/jbc.272.27.17012

• The oxidant stress of hyperhomocyst(e)inemia.

  Journal of Clinical Investigation · 1996 · 10.1172/jci118776

• Nitric oxide and its role in the cardiovascular system

  Progress in Cardiovascular Diseases · 1995 · 10.1016/s0033-0620(05)80001-5

• A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

  Nature · 1993 · 10.1038/364626a0

• Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen.

  Journal of Clinical Investigation · 1993 · 10.1172/jci116187

• Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.

  Proceedings of the National Academy of Sciences · 1993 · 10.1073/pnas.90.23.10957

• Biochemistry of Nitric Oxide and Its Redox-Activated Forms

  Science · 1992 · 10.1126/science.1281928

• Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.16.7674

Current projects

No projects listed.