Kenneth J. Livak

Research interests

Publications

• Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03704-y

• Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-020-01206-4

• Progressive immune dysfunction with advancing disease stage in renal cell carcinoma

  Cancer Cell · 2021 · https://doi.org/10.1016/j.ccell.2021.02.013

• Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

  Cancer Cell · 2019 · https://doi.org/10.1016/j.ccell.2019.08.005

• Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0792-9

• Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

  Nature · 2016 · https://doi.org/10.1038/nature20123

• CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq

  Genome biology · 2016 · https://doi.org/10.1186/s13059-016-0938-8

• Transcriptomic Characterization of SF3B1 Mutation Reveals Its Pleiotropic Effects in Chronic Lymphocytic Leukemia

  Cancer Cell · 2016 · https://doi.org/10.1016/j.ccell.2016.10.005

• Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms11589

• The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

  Nature Biotechnology · 2014 · https://doi.org/10.1038/nbt.2859

• Locally Disordered Methylation Forms the Basis of Intratumor Methylome Variation in Chronic Lymphocytic Leukemia

  Cancer Cell · 2014 · https://doi.org/10.1016/j.ccell.2014.10.012

• Analyzing real-time PCR data by the comparative CT method

  Nature Protocols · 2008 · https://doi.org/10.1038/nprot.2008.73

• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

  Methods · 2001 · https://doi.org/10.1006/meth.2001.1262

• Allelic discrimination using fluorogenic probes and the 5′ nuclease assay

  Genetic Analysis Biomolecular Engineering · 1999 · https://doi.org/10.1016/s1050-3862(98)00019-9

• Real time quantitative PCR.

  Genome Research · 1996 · https://doi.org/10.1101/gr.6.10.986

• The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus

  Human Genetics · 1996 · https://doi.org/10.1007/s004390050166

• Towards fully automated genome–wide polymorphism screening

  Nature Genetics · 1995 · https://doi.org/10.1038/ng0495-341

• Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization.

  Genome Research · 1995 · 10.1101/gr.4.6.357

• A hypervariable segment in the human dopamine receptor D4 (DRD4) gene

  Human Molecular Genetics · 1993 · https://doi.org/10.1093/hmg/2.6.767

• DNA polymorphisms amplified by arbitrary primers are useful as genetic markers

  Nucleic Acids Research · 1990 · https://doi.org/10.1093/nar/18.22.6531

• Complete nucleotide sequence of the AIDS virus, HTLV-III

  Nature · 1985 · 10.1038/313277a0

• ORGANIZATION AND MAPPING OF A SEQUENCE ON THE DROSOPHILA MELANOGASTER X AND Y CHROMOSOMES THAT IS TRANSCRIBED DURING SPERMATOGENESIS

  Genetics · 1984 · https://doi.org/10.1093/genetics/107.4.611

• The chromatin structure of specific genes: I. Evidence for higher order domains of defined DNA sequence

  Cell · 1979 · https://doi.org/10.1016/0092-8674(79)90095-3

Current projects

No projects listed.