Ramnik J. Xavier

Research interests

Publications

• Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

  Nature · 2021 · https://doi.org/10.1038/s41586-021-03832-5

• Trained immunity, tolerance, priming and differentiation: distinct immunological processes

  Nature Immunology · 2020 · 10.1038/s41590-020-00845-6

• Defining trained immunity and its role in health and disease

  Nature reviews. Immunology · 2020 · https://doi.org/10.1038/s41577-020-0285-6

• A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

  Nature · 2019 · https://doi.org/10.1038/s41586-019-0878-z

• Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

  Cell · 2019 · https://doi.org/10.1016/j.cell.2019.06.029

• BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

  Cell Host & Microbe · 2018 · 10.1016/j.chom.2017.12.010

• Gut microbiome structure and metabolic activity in inflammatory bowel disease

  Nature Microbiology · 2018 · https://doi.org/10.1038/s41564-018-0306-4

• Temporal development of the gut microbiome in early childhood from the TEDDY study

  Nature · 2018 · 10.1038/s41586-018-0617-x

• A single-cell survey of the small intestinal epithelium

  Nature · 2017 · 10.1038/nature24489

• Fine-mapping inflammatory bowel disease loci to single-variant resolution

  Nature · 2017 · 10.1038/nature22969

• CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

  Nature Medicine · 2016 · 10.1038/nm.4102

• Trained immunity: A program of innate immune memory in health and disease

  Science · 2016 · 10.1126/science.aaf1098

• The effect of host genetics on the gut microbiome

  Nature Genetics · 2016 · 10.1038/ng.3663

• Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

  Cell Metabolism · 2016 · 10.1016/j.cmet.2016.10.008

• Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

  Cell · 2016 · 10.1016/j.cell.2016.08.064

• Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

  Science · 2016 · 10.1126/science.aad3369

• Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

  Cell · 2016 · 10.1016/j.cell.2016.10.020

• Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

  Cell Metabolism · 2015 · 10.1016/j.cmet.2014.12.005

• CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

  Cell · 2014 · 10.1016/j.cell.2014.09.014

• The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

  Cell Host & Microbe · 2014 · https://doi.org/10.1016/j.chom.2014.02.005

• The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

  Gastroenterology · 2014 · 10.1053/j.gastro.2014.02.009

• Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

  Science · 2014 · 10.1126/science.1251086

• Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

  Nature Biotechnology · 2014 · 10.1038/nbt.3026

• mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

  Science · 2014 · 10.1126/science.1250684

• Succinate is an inflammatory signal that induces IL-1β through HIF-1α

  Nature · 2013 · https://doi.org/10.1038/nature11986

• Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1202870109

• Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

  Nature · 2012 · https://doi.org/10.1038/nature11582

• Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

  Cell Host & Microbe · 2012 · 10.1016/j.chom.2012.06.006

• Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

  Genome biology · 2012 · https://doi.org/10.1186/gb-2012-13-9-r79

• Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease

  Nature Genetics · 2011 · 10.1038/ng.952

• Genetics and pathogenesis of inflammatory bowel disease

  Nature · 2011 · 10.1038/nature10209

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

  Nature Genetics · 2011 · 10.1038/ng.764

• The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

  Cell · 2009 · 10.1016/j.cell.2009.12.017

• Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

  Nature · 2009 · https://doi.org/10.1038/nature08530

• Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

  Nature Genetics · 2008 · 10.1038/ng.175

• Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

  Science · 2008 · 10.1126/science.1152725

• A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

  Nature · 2008 · 10.1038/nature07416

• Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

  Nature Genetics · 2007 · 10.1038/ng2032

Current projects

No projects listed.