Benjamin L. Ebert

Research interests

Publications

• Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN

  Blood · 2022 · https://doi.org/10.1182/blood.2022016867

• International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data

  Blood · 2022 · https://doi.org/10.1182/blood.2022015850

• Molecular International Prognostic Scoring System for Myelodysplastic Syndromes

  NEJM Evidence · 2022 · https://doi.org/10.1056/evidoa2200008

• Cancer therapy shapes the fitness landscape of clonal hematopoiesis

  Nature Genetics · 2020 · 10.1038/s41588-020-00710-0

• Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-1008-z

• Clonal hematopoiesis in human aging and disease

  Science · 2019 · 10.1126/science.aan4673

• Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

  Science Translational Medicine · 2018 · https://doi.org/10.1126/scitranslmed.aan8292

• Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease

  New England Journal of Medicine · 2017 · 10.1056/nejmoa1701719

• Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

  Blood · 2016 · https://doi.org/10.1182/blood-2016-08-733196

• Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells

  Genome Research · 2015 · 10.1101/gr.192237.115

• Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

  Blood · 2015 · 10.1182/blood-2015-03-631747

• Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

  Nature · 2015 · 10.1038/nature14610

• Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

  Blood · 2014 · 10.1182/blood-2014-11-610543

• Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

  New England Journal of Medicine · 2014 · https://doi.org/10.1056/nejmoa1408617

• Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

  Cell stem cell · 2014 · 10.1016/j.stem.2014.11.004

• Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation

  Nature Biotechnology · 2014 · 10.1038/nbt.3026

• Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

  Science · 2013 · 10.1126/science.1244851

• Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

  Science · 2013 · https://doi.org/10.1126/science.1247005

• Clinical Effect of Point Mutations in Myelodysplastic Syndromes

  New England Journal of Medicine · 2011 · 10.1056/nejmoa1013343

• Stem cell gene expression programs influence clinical outcome in human leukemia

  Nature Medicine · 2011 · 10.1038/nm.2415

• Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

  Cell · 2011 · 10.1016/j.cell.2011.01.004

• Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

  Nature · 2010 · 10.1038/nature08851

• The landscape of somatic copy-number alteration across human cancers

  Nature · 2010 · 10.1038/nature08822

• Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

  Nature · 2008 · 10.1038/nature06494

• MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

  PLoS Medicine · 2006 · 10.1371/journal.pmed.0030270

• Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

  Cancer Cell · 2005 · 10.1016/j.ccr.2005.03.023

• Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0506580102

• MicroRNA expression profiles classify human cancers

  Nature · 2005 · https://doi.org/10.1038/nature03702

Current projects

No projects listed.