Philip L. De Jager

Research interests

Publications

• Neuroinflammation in Alzheimer disease

  Nature reviews. Immunology · 2024 · https://doi.org/10.1038/s41577-024-01104-7

• Locus for severity implicates CNS resilience in progression of multiple sclerosis

  Nature · 2023 · https://doi.org/10.1038/s41586-023-06250-x

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• Gut Microbiome in Progressive Multiple Sclerosis

  Annals of Neurology · 2021 · https://doi.org/10.1002/ana.26084

• Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer’s disease

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-020-19737-2

• Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

  Nature Communications · 2020 · https://doi.org/10.1038/s41467-019-14279-8

• Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0815-6

• Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

  Alzheimer s & Dementia · 2017 · https://doi.org/10.1016/j.jalz.2016.12.012

• Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

  Nature Communications · 2017 · https://doi.org/10.1038/s41467-017-00031-7

• Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

  Alzheimer s & Dementia · 2017 · https://doi.org/10.1016/j.jalz.2016.12.012

• Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

  Science · 2017 · 10.1126/science.aah4573

• Assessment of the genetic variance of late-onset Alzheimer's disease

  Neurobiology of Aging · 2016 · https://doi.org/10.1016/j.neurobiolaging.2016.02.024

• Alterations of the human gut microbiome in multiple sclerosis

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms12015

• New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

  Nature Communications · 2016 · https://doi.org/10.1038/ncomms10495

• A novel Alzheimer disease locus located near the gene encoding tau protein

  Molecular Psychiatry · 2015 · https://doi.org/10.1038/mp.2015.23

• Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

  Molecular Psychiatry · 2015 · https://doi.org/10.1038/mp.2014.188

• Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

  The American Journal of Human Genetics · 2015 · 10.1016/j.ajhg.2015.09.001

• Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

  Nature Neuroscience · 2014 · 10.1038/nn.3786

• Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease

  JAMA Neurology · 2014 · https://doi.org/10.1001/jamaneurol.2014.1491

• Convergent genetic and expression data implicate immunity in Alzheimer's disease

  Alzheimer s & Dementia · 2014 · https://doi.org/10.1016/j.jalz.2014.05.1757

• Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

  PLoS ONE · 2014 · 10.1371/journal.pone.0094661

• Genetics of rheumatoid arthritis contributes to biology and drug discovery

  Nature · 2013 · 10.1038/nature12873

• Charting a dynamic DNA methylation landscape of the human genome

  Nature · 2013 · 10.1038/nature12433

• Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

  Nature Genetics · 2013 · 10.1038/ng.2770

• GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

  Science · 2013 · 10.1126/science.1235488

• Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

  Nature Genetics · 2013 · 10.1038/ng.2802

• Common variants at 12q14 and 12q24 are associated with hippocampal volume

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2237

• Multicolored stain-free histopathology with coherent Raman imaging

  Laboratory Investigation · 2012 · https://doi.org/10.1038/labinvest.2012.109

• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

  Nature Genetics · 2011 · 10.1038/ng.801

• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

  Nature Genetics · 2010 · 10.1038/ng.582

• Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein

  Nature Medicine · 2007 · https://doi.org/10.1038/nm1488

Current projects

No projects listed.