Lan Nguyễn

Research interests

Publications

• Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

  Nature Genetics · 2022 · 10.1038/s41588-022-01134-8

• Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

  Immunity · 2022 · 10.1016/j.immuni.2021.12.001

• Spatially organized multicellular immune hubs in human colorectal cancer

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.08.003

• A cellular and spatial map of the choroid plexus across brain ventricles and ages

  Cell · 2021 · 10.1016/j.cell.2021.04.003

• Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma

  Nature Medicine · 2021 · 10.1038/s41591-020-01212-6

• Disease-associated astrocytes in Alzheimer’s disease and aging

  Nature Neuroscience · 2020 · https://doi.org/10.1038/s41593-020-0624-8

• A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors

  Nature Medicine · 2020 · 10.1038/s41591-020-0844-1

• Systematic comparison of single-cell and single-nucleus RNA-sequencing methods

  Nature Biotechnology · 2020 · https://doi.org/10.1038/s41587-020-0465-8

• In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes

  Science · 2020 · 10.1126/science.aaz6063

• Benchmarking single-cell RNA-sequencing protocols for cell atlas projects

  Nature Biotechnology · 2020 · https://doi.org/10.1038/s41587-020-0469-4

• Systematic comparative analysis of single cell RNA-sequencing methods

  bioRxiv (Cold Spring Harbor Laboratory) · 2019 · 10.1101/632216

• Nuclei multiplexing with barcoded antibodies for single-nucleus genomics

  Nature Communications · 2019 · 10.1038/s41467-019-10756-2

• Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

  Cell · 2019 · 10.1016/j.cell.2019.06.029

• Single-cell transcriptomic profiling of the aging mouse brain

  Nature Neuroscience · 2019 · 10.1038/s41593-019-0491-3

• Single-Cell Analysis of the Normal Mouse Aorta Reveals Functionally Distinct Endothelial Cell Populations

  Circulation · 2019 · 10.1161/circulationaha.118.038362

• Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1289-x

• Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

  Immunity · 2019 · 10.1016/j.immuni.2019.09.004

• Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

  Nature Communications · 2019 · 10.1038/s41467-019-13382-0

• T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

  Cell · 2018 · 10.1016/j.cell.2018.10.008

• A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

  Nature · 2018 · 10.1038/s41586-018-0393-7

• Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population‐based sample of children

  Clinical & Experimental Allergy · 2003 · 10.1046/j.1365-2222.2003.01800.x

Current projects

No projects listed.