Jianjun Gao

Research interests

Publications

• Patient‐Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy

  Advanced Science · 2022 · https://doi.org/10.1002/advs.202204097

• 9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy

  Nature Communications · 2021 · https://doi.org/10.1038/s41467-021-25894-9

• The Next Decade of Immune Checkpoint Therapy

  Cancer Discovery · 2021 · https://doi.org/10.1158/2159-8290.cd-20-1680

• Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

  BioScience Trends · 2020 · https://doi.org/10.5582/bst.2020.01047

• Assessment of Luminal and Basal Phenotypes in Bladder Cancer

  Scientific Reports · 2020 · https://doi.org/10.1038/s41598-020-66747-7

• B cells and tertiary lymphoid structures promote immunotherapy response

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1922-8

• Neoadjuvant PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable high-risk urothelial carcinoma

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-1086-y

• Discovering drugs to treat coronavirus disease 2019 (COVID-19)

  Drug Discoveries & Therapeutics · 2020 · https://doi.org/10.5582/ddt.2020.01012

• Resumption of Immune Checkpoint Inhibitor Therapy After Immune-Mediated Colitis

  Journal of Clinical Oncology · 2019 · https://doi.org/10.1200/jco.19.00320

• Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer

  Cell stem cell · 2019 · https://doi.org/10.1016/j.stem.2019.10.010

• What Is the Significance of Variant Histology in Urothelial Carcinoma?

  European Urology Focus · 2019 · https://doi.org/10.1016/j.euf.2019.09.003

• Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy

  Nature Metabolism · 2019 · https://doi.org/10.1038/s42255-019-0045-8

• Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities

  Proceedings of the National Academy of Sciences · 2019 · https://doi.org/10.1073/pnas.1908079116

• Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0238-9

• VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer

  Nature Medicine · 2017 · 10.1038/nm.4308

• TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0256

• Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy

  Cell · 2016 · https://doi.org/10.1016/j.cell.2016.08.069

• Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

  Proceedings of the National Academy of Sciences · 2016 · https://doi.org/10.1073/pnas.1611421113

• Resistance to Antiangiogenic Therapy Is Associated with an Immunosuppressive Tumor Microenvironment in Metastatic Renal Cell Carcinoma

  Cancer Immunology Research · 2015 · https://doi.org/10.1158/2326-6066.cir-14-0244

• Renal cell carcinoma

  BMJ · 2014 · https://doi.org/10.1136/bmj.g4797

• Chinese herbal medicines as adjuvant treatment during chemo- or radio-therapy for cancer.

  PubMed · 2010

• An Interferon-γ-activated Site (GAS) Is Necessary for Full Expression of the Mouse iNOS Gene in Response to Interferon-γ and Lipopolysaccharide

  Journal of Biological Chemistry · 1997 · https://doi.org/10.1074/jbc.272.2.1226

Current projects

No projects listed.