Sarah A. Teichmann

Research interests

Publications

• Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer

  Cancer Cell · 2022 · https://doi.org/10.1016/j.ccell.2022.11.001

• Cross-tissue immune cell analysis reveals tissue-specific features in humans

  Science · 2022 · https://doi.org/10.1126/science.abl5197

• SARS-CoV-2 infection of the oral cavity and saliva

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01296-8

• Single-cell multi-omics analysis of the immune response in COVID-19

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01329-2

• Local and systemic responses to SARS-CoV-2 infection in children and adults

  Nature · 2021 · https://doi.org/10.1038/s41586-021-04345-x

• Differential abundance testing on single-cell data using k-nearest neighbor graphs

  Nature Biotechnology · 2021 · 10.1038/s41587-021-01033-z

• CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

  Nature Protocols · 2020 · https://doi.org/10.1038/s41596-020-0292-x

• Cells of the adult human heart

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2797-4

• High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.04.036

• Establishment of porcine and human expanded potential stem cells

  Nature Cell Biology · 2019 · https://doi.org/10.1038/s41556-019-0333-2

• Resolving the fibrotic niche of human liver cirrhosis at single-cell level

  Nature · 2019 · https://doi.org/10.1038/s41586-019-1631-3

• BBKNN: fast batch alignment of single cell transcriptomes

  Bioinformatics · 2019 · 10.1093/bioinformatics/btz625

• A cellular census of human lungs identifies novel cell states in health and in asthma

  Nature Medicine · 2019 · 10.1038/s41591-019-0468-5

• The Human Lung Cell Atlas: A High-Resolution Reference Map of the Human Lung in Health and Disease

  American Journal of Respiratory Cell and Molecular Biology · 2019 · https://doi.org/10.1165/rcmb.2018-0416tr

• Spatiotemporal immune zonation of the human kidney

  Science · 2019 · https://doi.org/10.1126/science.aat5031

• Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

  Cell · 2019 · https://doi.org/10.1016/j.cell.2018.11.044

• Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

  Science · 2018 · 10.1126/science.aat1699

• Exponential scaling of single-cell RNA-seq in the past decade

  Nature Protocols · 2018 · 10.1038/nprot.2017.149

• A rapid and robust method for single cell chromatin accessibility profiling

  Nature Communications · 2018 · 10.1038/s41467-018-07771-0

• Single-cell reconstruction of the early maternal–fetal interface in humans

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0698-6

• A practical guide to single-cell RNA-sequencing for biomedical research and clinical applications

  Genome Medicine · 2017 · 10.1186/s13073-017-0467-4

• The Human Cell Atlas

  Zurich Open Repository and Archive (University of Zurich) · 2017 · 10.5167/uzh-162597

• A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

  Cell Reports · 2016 · 10.1016/j.celrep.2016.09.079

• Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

  Nature Biotechnology · 2015 · 10.1038/nbt.3102

• Computational assignment of cell-cycle stage from single-cell transcriptome data

  Methods · 2015 · https://doi.org/10.1016/j.ymeth.2015.06.021

• Computational and analytical challenges in single-cell transcriptomics

  Nature Reviews Genetics · 2015 · 10.1038/nrg3833

• The Technology and Biology of Single-Cell RNA Sequencing

  Molecular Cell · 2015 · 10.1016/j.molcel.2015.04.005

• Accounting for technical noise in single-cell RNA-seq experiments

  Nature Methods · 2013 · 10.1038/nmeth.2645

• Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer

  Proceedings of the National Academy of Sciences · 2013 · https://doi.org/10.1073/pnas.1320318110

• An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man

  Cell · 2010 · https://doi.org/10.1016/j.cell.2010.01.044

• A census of human transcription factors: function, expression and evolution

  Nature Reviews Genetics · 2009 · 10.1038/nrg2538

• A HaemAtlas: characterizing gene expression in differentiated human blood cells

  Blood · 2009 · https://doi.org/10.1182/blood-2008-06-162958

• Common variants near MC4R are associated with fat mass, weight and risk of obesity

  Nature Genetics · 2008 · 10.1038/ng.140

• Genomic analysis of regulatory network dynamics reveals large topological changes

  Nature · 2004 · 10.1038/nature02782

• Evolution of the Protein Repertoire

  Science · 2003 · https://doi.org/10.1126/science.1085371

• Supra-domains: Evolutionary Units Larger than Single Protein Domains

  Journal of Molecular Biology · 2003 · https://doi.org/10.1016/j.jmb.2003.12.026

• Domain combinations in archaeal, eubacterial and eukaryotic proteomes

  Journal of Molecular Biology · 2001 · https://doi.org/10.1006/jmbi.2001.4776

Current projects

No projects listed.