Nick Barker
Researcher Next ID · RN-019874
Researcher · Medicine
Colchester, Singapore
- Works count
- 208
- Citation count
- 53,665
- H-index
- 73
- i10-index
- 114
Research interests
Publications
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Cancer Research · 2019 · https://doi.org/10.1158/0008-5472.can-18-2095
Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer
Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.11.018
Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5+ Stem Cells
Stem Cell Reports · 2015 · https://doi.org/10.1016/j.stemcr.2015.03.003
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
Nature Cell Biology · 2012 · https://doi.org/10.1038/ncb2581
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
The EMBO Journal · 2012 · https://doi.org/10.1038/emboj.2012.166
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
Nature · 2011 · https://doi.org/10.1038/nature10337
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
Cell stem cell · 2010 · 10.1016/j.stem.2009.11.013
Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
Cell · 2010 · https://doi.org/10.1016/j.cell.2010.09.016
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
Nature · 2010 · https://doi.org/10.1038/nature09637
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Nature · 2009 · 10.1038/nature07935
Crypt stem cells as the cells-of-origin of intestinal cancer
Nature · 2008 · 10.1038/nature07602
Identification of stem cells in small intestine and colon by marker gene Lgr5
Nature · 2007 · 10.1038/nature06196
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
Nature Genetics · 1998 · 10.1038/1270
Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
Science · 1997 · 10.1126/science.275.5307.1784
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Science · 1997 · 10.1126/science.275.5307.1787
Current projects
No projects listed.