Zachary Heins

Research interests

Publications

• Integration and Analysis of CPTAC Proteomics Data in the Context of Cancer Genomics in the cBioPortal

  Molecular & Cellular Proteomics · 2019 · 10.1074/mcp.tir119.001673

• Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.03.010

• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.050

• An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.02.052

• Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.07.001

• Oncogenic Signaling Pathways in The Cancer Genome Atlas

  Cell · 2018 · 10.1016/j.cell.2018.03.035

• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

  Cell · 2018 · 10.1016/j.cell.2018.03.034

• Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.046

• Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.077

• A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.03.027

• Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.064

• Systematic Analysis of Splice-Site-Creating Mutations in Cancer

  Cell Reports · 2018 · https://doi.org/10.1016/j.celrep.2018.03.052

• Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.03.022

• Genomic and Functional Approaches to Understanding Cancer Aneuploidy

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.007

• Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

  Cell Reports · 2018 · 10.1016/j.celrep.2018.03.086

• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

  Cell Systems · 2018 · 10.1016/j.cels.2018.03.002

• Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

  Cell Reports · 2018 · 10.1016/j.celrep.2018.10.001

• lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

  Cancer Cell · 2018 · 10.1016/j.ccell.2018.03.006

• Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

  Cell Reports · 2018 · 10.1016/j.celrep.2018.01.088

• Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

  Cell Systems · 2018 · https://doi.org/10.1016/j.cels.2018.03.003

• AACR Project GENIE: Powering Precision Medicine through an International Consortium

  Cancer Discovery · 2017 · 10.1158/2159-8290.cd-17-0151

• Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0787

• Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making

  JCO Precision Oncology · 2017 · https://doi.org/10.1200/po.17.00029

• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

  Nature Medicine · 2017 · 10.1038/nm.4333

• Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

  Gastroenterology · 2016 · https://doi.org/10.1053/j.gastro.2016.04.001

Current projects

No projects listed.