Christopher S. Chen

Research interests

Publications

• Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study

  The Lancet Oncology · 2023 · https://doi.org/10.1016/s1470-2045(23)00150-x

• Mechanical regulation of glycolysis via cytoskeleton architecture

  Nature · 2020 · https://doi.org/10.1038/s41586-020-1998-1

• Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.03.001

• Laminar flow downregulates Notch activity to promote lymphatic sprouting

  Journal of Clinical Investigation · 2017 · https://doi.org/10.1172/jci87442

• Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

  Science · 2015 · https://doi.org/10.1126/science.aaa5458

• Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

  Nature Materials · 2015 · https://doi.org/10.1038/nmat4444

• Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

  Nature Materials · 2013 · https://doi.org/10.1038/nmat3586

• Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

  Journal of Cell Science · 2012 · https://doi.org/10.1242/jcs.079509

• Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

  Nature Materials · 2012 · https://doi.org/10.1038/nmat3357

• Mechanical regulation of cell function with geometrically modulated elastomeric substrates

  Nature Methods · 2010 · https://doi.org/10.1038/nmeth.1487

• Measurement of mechanical tractions exerted by cells in three-dimensional matrices

  Nature Methods · 2010 · https://doi.org/10.1038/nmeth.1531

• Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

  Nature · 2010 · https://doi.org/10.1038/nature09198

• Mechanical tugging force regulates the size of cell–cell junctions

  Proceedings of the National Academy of Sciences · 2010 · https://doi.org/10.1073/pnas.0914547107

• Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

  Cell stem cell · 2009 · https://doi.org/10.1016/j.stem.2009.06.016

• Mechanotransduction in development: a growing role for contractility

  Nature Reviews Molecular Cell Biology · 2008 · https://doi.org/10.1038/nrm2592

• Versatile, Fully Automated, Microfluidic Cell Culture System

  Analytical Chemistry · 2007 · https://doi.org/10.1021/ac071311w

• Nanopattern-induced changes in morphology and motility of smooth muscle cells

  Biomaterials · 2005 · https://doi.org/10.1016/j.biomaterials.2005.01.058

• Emergent patterns of growth controlled by multicellular form and mechanics

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0502575102

• Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

  Developmental Cell · 2004 · https://doi.org/10.1016/s1534-5807(04)00075-9

• Cells lying on a bed of microneedles: An approach to isolate mechanical force

  Proceedings of the National Academy of Sciences · 2003 · https://doi.org/10.1073/pnas.0235407100

• Micropatterned Surfaces for Control of Cell Shape, Position, and Function

  Biotechnology Progress · 1998 · https://doi.org/10.1021/bp980031m

• Geometric Control of Cell Life and Death

  Science · 1997 · 10.1126/science.276.5317.1425

• Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.3.849

Current projects

No projects listed.