James Brett Case

Research interests

Publications

• SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

  Nature · 2022 · https://doi.org/10.1038/s41586-022-04441-6

• Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

  Nature Microbiology · 2021 · 10.1038/s41564-021-00972-2

• SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

  Nature · 2021 · 10.1038/s41586-021-03738-2

• Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

  Nature Medicine · 2021 · https://doi.org/10.1038/s41591-021-01294-w

• The antigenic anatomy of SARS-CoV-2 receptor binding domain

  Cell · 2021 · 10.1016/j.cell.2021.02.032

• Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

  Cell · 2021 · 10.1016/j.cell.2021.02.026

• In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains

  Nature · 2021 · 10.1038/s41586-021-03720-y

• A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

  Cell · 2020 · 10.1016/j.cell.2020.06.011

• Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

  Nature Medicine · 2020 · 10.1038/s41591-020-0998-x

• Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2

  Cell Host & Microbe · 2020 · 10.1016/j.chom.2020.06.021

• A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection

  The Journal of Immunology · 2020 · 10.4049/jimmunol.2000583

• Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2349-y

• Potently neutralizing and protective human antibodies against SARS-CoV-2

  Nature · 2020 · https://doi.org/10.1038/s41586-020-2548-6

• Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

  Science · 2020 · https://doi.org/10.1126/science.abe3354

• De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

  Science · 2020 · 10.1126/science.abd9909

• Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

  Nature Immunology · 2020 · 10.1038/s41590-020-00814-z

• A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

  Cell · 2020 · 10.1016/j.cell.2020.08.026

• Growth, detection, quantification, and inactivation of SARS-CoV-2

  Virology · 2020 · 10.1016/j.virol.2020.05.015

• Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

  Proceedings of the National Academy of Sciences · 2020 · 10.1073/pnas.2012197117

• Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

  mBio · 2018 · https://doi.org/10.1128/mbio.00221-18

• Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

  Science Translational Medicine · 2017 · https://doi.org/10.1126/scitranslmed.aal3653

Current projects

No projects listed.