- Works count
- 252
- Citation count
- 11,603
- H-index
- 59
- i10-index
- 136
Research interests
Publications
Unleashing the Power of Bond Cleavage Chemistry in Living Systems
ACS Central Science · 2021 · https://doi.org/10.1021/acscentsci.1c00124
Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein Degradation
Journal of the American Chemical Society · 2021 · https://doi.org/10.1021/jacs.1c08521
SAR1B senses leucine levels to regulate mTORC1 signalling
Nature · 2021 · https://doi.org/10.1038/s41586-021-03768-w
Time-resolved protein activation by proximal decaging in living systems
Nature · 2019 · https://doi.org/10.1038/s41586-019-1188-1
Synergistic enzymatic and bioorthogonal reactions for selective prodrug activation in living systems
Nature Communications · 2018 · https://doi.org/10.1038/s41467-018-07490-6
ALKBH10B Is an RNA N 6 -Methyladenosine Demethylase Affecting Arabidopsis Floral Transition
The Plant Cell · 2017 · https://doi.org/10.1105/tpc.16.00912
Optimized Tetrazine Derivatives for Rapid Bioorthogonal Decaging in Living Cells
Angewandte Chemie International Edition · 2016 · https://doi.org/10.1002/anie.201608009
Bioorthogonal Chemical Activation of Kinases in Living Systems
ACS Central Science · 2016 · https://doi.org/10.1021/acscentsci.6b00024
Development and application of bond cleavage reactions in bioorthogonal chemistry
Nature Chemical Biology · 2016 · https://doi.org/10.1038/nchembio.2024
Endovascular Therapy for Acute Ischemic Stroke With Occlusion of the Middle Cerebral Artery M2 Segment
JAMA Neurology · 2016 · https://doi.org/10.1001/jamaneurol.2016.2773
Illuminating biological processes through site-specific protein labeling
Chemical Society Reviews · 2015 · https://doi.org/10.1039/c4cs00393d
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
Nature Cell Biology · 2015 · https://doi.org/10.1038/ncb3255
Transition metal-mediated bioorthogonal protein chemistry in living cells
Chemical Society Reviews · 2014 · https://doi.org/10.1039/c4cs00117f
Diels-Alder reaction–triggered bioorthogonal protein decaging in living cells
Nature Chemical Biology · 2014 · https://doi.org/10.1038/nchembio.1656
Palladium-triggered deprotection chemistry for protein activation in living cells
Nature Chemistry · 2014 · https://doi.org/10.1038/nchem.1887
Ligand-Free Palladium-Mediated Site-Specific Protein Labeling Inside Gram-Negative Bacterial Pathogens
Journal of the American Chemical Society · 2013 · https://doi.org/10.1021/ja402424j
The multiple antibiotic resistance regulator MarR is a copper sensor in Escherichia coli
Nature Chemical Biology · 2013 · https://doi.org/10.1038/nchembio.1380
A genetically incorporated crosslinker reveals chaperone cooperation in acid resistance
Nature Chemical Biology · 2011 · https://doi.org/10.1038/nchembio.644
A Facile System for Encoding Unnatural Amino Acids in Mammalian Cells
Angewandte Chemie International Edition · 2009 · https://doi.org/10.1002/anie.200900683
The Pseudomonas aeruginosa multidrug efflux regulator MexR uses an oxidation-sensing mechanism
Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0803391105
Design of an Emission Ratiometric Biosensor from MerR Family Proteins: A Sensitive and Selective Sensor for Hg2+
Journal of the American Chemical Society · 2007 · https://doi.org/10.1021/ja068342d
An oxidation-sensing mechanism is used by the global regulator MgrA in Staphylococcus aureus
Nature Chemical Biology · 2006 · https://doi.org/10.1038/nchembio820
An Exceptionally Selective Lead( II )‐Regulatory Protein from Ralstonia Metallidurans : Development of a Fluorescent Lead( II ) Probe
Angewandte Chemie International Edition · 2005 · https://doi.org/10.1002/anie.200462443
A General Strategy to Convert the MerR Family Proteins into Highly Sensitive and Selective Fluorescent Biosensors for Metal Ions
Journal of the American Chemical Society · 2003 · https://doi.org/10.1021/ja0383975
Current projects
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