Xiaoguang Lei

Research interests

Publications

• Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III

  Science · 2024 · 10.1126/science.adj3484

• Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target

  Science · 2023 · 10.1126/science.add5787

• A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration

  Cell stem cell · 2022 · 10.1016/j.stem.2022.03.009

• An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence

  Cell Host & Microbe · 2020 · 10.1016/j.chom.2020.03.004

• Late-Stage Diversification of Natural Products

  ACS Central Science · 2020 · 10.1021/acscentsci.9b00916

• Click-ExM enables expansion microscopy for all biomolecules

  Nature Methods · 2020 · https://doi.org/10.1038/s41592-020-01005-2

• FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

  Nature Chemistry · 2020 · 10.1038/s41557-020-0467-7

• MRGPRX4 is a bile acid receptor for human cholestatic itch

  eLife · 2019 · 10.7554/elife.48431

• Chemoproteomic Profiling of Bile Acid Interacting Proteins

  ACS Central Science · 2017 · 10.1021/acscentsci.7b00134

• Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states

  eLife · 2016 · 10.7554/elife.12509

• Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome

  Journal of Medicinal Chemistry · 2016 · 10.1021/acs.jmedchem.6b01196

• Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis

  Cell chemical biology · 2016 · 10.1016/j.chembiol.2015.08.018

• Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine

  Nature Communications · 2015 · 10.1038/ncomms7522

• A Bioorthogonal Ligation Enabled by Click Cycloaddition of o-Quinolinone Quinone Methide and Vinyl Thioether

  Journal of the American Chemical Society · 2013 · 10.1021/ja401989p

• Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

  Cell · 2012 · https://doi.org/10.1016/j.cell.2011.11.031

• Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

  Nature Chemical Biology · 2012 · 10.1038/nchembio.1153

• Total Syntheses of Lycopodium Alkaloids (+)‐Fawcettimine, (+)‐Fawcettidine, and (−)‐8‐Deoxyserratinine

  Angewandte Chemie International Edition · 2011 · 10.1002/anie.201106753

• Crystal structure of the FTO protein reveals basis for its substrate specificity

  Nature · 2010 · 10.1038/nature08921

• Chemical probing reveals insights into the signaling mechanism of inflammasome activation

  Cell Research · 2010 · 10.1038/cr.2010.135

Current projects

No projects listed.