Kresten Lindorff‐Larsen

Research interests

Publications

• Conformational ensembles of the human intrinsically disordered proteome

  Nature · 2024 · 10.1038/s41586-023-07004-5

• A structural biology community assessment of AlphaFold2 applications

  Nature Structural & Molecular Biology · 2022 · https://doi.org/10.1038/s41594-022-00849-w

• Accurate model of liquid–liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties

  Proceedings of the National Academy of Sciences · 2021 · 10.1073/pnas.2111696118

• Integrating Molecular Simulation and Experimental Data: A Bayesian/Maximum Entropy Reweighting Approach

  Methods in molecular biology · 2020 · https://doi.org/10.1007/978-1-0716-0270-6_15

• Biophysical and Mechanistic Models for Disease-Causing Protein Variants

  Trends in Biochemical Sciences · 2019 · https://doi.org/10.1016/j.tibs.2019.01.003

• Promoting transparency and reproducibility in enhanced molecular simulations

  Nature Methods · 2019 · https://doi.org/10.1038/s41592-019-0506-8

• Biophysical experiments and biomolecular simulations: A perfect match?

  Science · 2018 · 10.1126/science.aat4010

• Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

  Molecular Cell · 2018 · 10.1016/j.molcel.2018.08.027

• The Role of Protein Loops and Linkers in Conformational Dynamics and Allostery

  Chemical Reviews · 2016 · 10.1021/acs.chemrev.5b00623

• Combining Experiments and Simulations Using the Maximum Entropy Principle

  PLoS Computational Biology · 2014 · https://doi.org/10.1371/journal.pcbi.1003406

• Atomic-level description of ubiquitin folding

  Proceedings of the National Academy of Sciences · 2013 · 10.1073/pnas.1218321110

• Systematic Validation of Protein Force Fields against Experimental Data

  PLoS ONE · 2012 · 10.1371/journal.pone.0032131

• Protein folding kinetics and thermodynamics from atomistic simulation

  Proceedings of the National Academy of Sciences · 2012 · 10.1073/pnas.1201811109

• Structure and Dynamics of an Unfolded Protein Examined by Molecular Dynamics Simulation

  Journal of the American Chemical Society · 2012 · https://doi.org/10.1021/ja209931w

• How Fast-Folding Proteins Fold

  Science · 2011 · https://doi.org/10.1126/science.1208351

• How Robust Are Protein Folding Simulations with Respect to Force Field Parameterization?

  Biophysical Journal · 2011 · https://doi.org/10.1016/j.bpj.2011.03.051

• Improved side‐chain torsion potentials for the Amber ff99SB protein force field

  Proteins Structure Function and Bioinformatics · 2010 · 10.1002/prot.22711

• Principles of conduction and hydrophobic gating in K + channels

  Proceedings of the National Academy of Sciences · 2010 · 10.1073/pnas.0911691107

• Atomic-Level Characterization of the Structural Dynamics of Proteins

  Science · 2010 · https://doi.org/10.1126/science.1187409

• Millisecond-scale molecular dynamics simulations on Anton

  · 2009 · 10.1145/1654059.1654099

• Millisecond-scale molecular dynamics simulations on Anton

  · 2009 · 10.1145/1654059.1654126

• Long-timescale molecular dynamics simulations of protein structure and function

  Current Opinion in Structural Biology · 2009 · 10.1016/j.sbi.2009.03.004

• Microsecond Molecular Dynamics Simulation Shows Effect of Slow Loop Dynamics on Backbone Amide Order Parameters of Proteins

  The Journal of Physical Chemistry B · 2008 · https://doi.org/10.1021/jp077018h

• Simultaneous determination of protein structure and dynamics

  Nature Cell Biology · 2005 · 10.1038/nature03199

• Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

  Journal of the American Chemical Society · 2004 · 10.1021/ja044834j

Current projects

No projects listed.