Amy B. Heimberger

Research interests

Publications

• Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy

  Journal of Clinical Investigation · 2023 · https://doi.org/10.1172/jci163446

• Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma

  Nature Medicine · 2019 · https://doi.org/10.1038/s41591-019-0694-x

• Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target

  Journal of Clinical Investigation · 2018 · https://doi.org/10.1172/jci121266

• Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial

  The Lancet Oncology · 2017 · https://doi.org/10.1016/s1470-2045(17)30414-x

• Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment

  Cancer Cell · 2017 · https://doi.org/10.1016/j.ccell.2017.06.003

• Mutational burden, immune checkpoint expression, and mismatch repair in glioma: implications for immune checkpoint immunotherapy

  Neuro-Oncology · 2017 · https://doi.org/10.1093/neuonc/nox026

• Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

  OncoImmunology · 2017 · https://doi.org/10.1080/2162402x.2017.1412909

• Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype

  JCI Insight · 2016 · https://doi.org/10.1172/jci.insight.85841

• PD-L1 expression and prognostic impact in glioblastoma

  Neuro-Oncology · 2015 · https://doi.org/10.1093/neuonc/nov172

• Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

  Cancer Research · 2015 · https://doi.org/10.1158/0008-5472.can-15-0139

• A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study

  Neuro-Oncology · 2015 · https://doi.org/10.1093/neuonc/nou348

• Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.08.001

• Glioma cancer stem cells induce immunosuppressive macrophages/microglia

  Neuro-Oncology · 2010 · https://doi.org/10.1093/neuonc/noq082

• Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

  Journal of Clinical Oncology · 2010 · https://doi.org/10.1200/jco.2010.28.6963

• Altered adenosine-to-inosine RNA editing in human cancer

  Genome Research · 2007 · https://doi.org/10.1101/gr.6493107

• The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses1

  Neuro-Oncology · 2006 · https://doi.org/10.1215/15228517-2006-008

• Prognostic Effect of Epidermal Growth Factor Receptor and EGFRvIII in Glioblastoma Multiforme Patients

  Clinical Cancer Research · 2005 · https://doi.org/10.1158/1078-0432.ccr-04-1737

• Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

  Proceedings of the National Academy of Sciences · 1992 · https://doi.org/10.1073/pnas.89.13.6065

• Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo

  Science · 1990 · https://doi.org/10.1126/science.2125367

Current projects

No projects listed.