Hiroaki Kiyokawa

Research interests

Publications

• Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

  Nature · 2008 · 10.1038/nature07267

• Requirement for CDK4 kinase function in breast cancer

  Cancer Cell · 2006 · 10.1016/j.ccr.2005.12.012

• Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation

  Developmental Cell · 2006 · 10.1016/j.devcel.2006.03.004

• Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner

  Cancer Cell · 2006 · 10.1016/j.ccr.2006.08.022

• Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity

  Diabetes · 2006 · 10.2337/diabetes.55.02.06.db05-0757

• Cdk4 promotes adipogenesis through PPARγ activation

  Cell Metabolism · 2005 · 10.1016/j.cmet.2005.09.003

• Cdc2–cyclin E complexes regulate the G1/S phase transition

  Nature Cell Biology · 2005 · 10.1038/ncb1284

• Lack of Cyclin-Dependent Kinase 4 Inhibits c- myc Tumorigenic Activities in Epithelial Tissues

  Molecular and Cellular Biology · 2004 · 10.1128/mcb.24.17.7538-7547.2004

• The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis

  Developmental Biology · 2004 · 10.1016/j.ydbio.2004.08.022

• Loss of cyclin‐dependent kinase inhibitors produces adipocyte hyperplasia and obesity

  The FASEB Journal · 2004 · 10.1096/fj.04-2631fje

• The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

  Proceedings of the National Academy of Sciences · 2002 · 10.1073/pnas.252570299

• Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence

  Genes & Development · 2002 · 10.1101/gad.1033002

• The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1

  Molecular and Cellular Biology · 2001 · 10.1128/mcb.21.14.4818-4828.2001

• Regulatory Role of p27kip1 in the Mouse and Human Testis*

  Endocrinology · 1999 · 10.1210/endo.140.4.6638

• Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity

  Molecular and Cellular Biology · 1999 · 10.1128/mcb.19.10.7011

• Enhanced Ribosomal Association of p27Kip1 mRNA Is a Mechanism Contributing to Accumulation during Growth Arrest

  Journal of Biological Chemistry · 1997 · 10.1074/jbc.272.11.7093

• Posttranslational regulation of cyclin D1 by retinoic acid: A chemoprevention mechanism

  Proceedings of the National Academy of Sciences · 1997 · 10.1073/pnas.94.22.12070

• Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1

  Genes & Development · 1997 · 10.1101/gad.11.18.2335

• Rapamycin Resistance Tied to Defective Regulation of p27 Kip1

  Molecular and Cellular Biology · 1996 · 10.1128/mcb.16.12.6744

• Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27

  Cell · 1996 · https://doi.org/10.1016/s0092-8674(00)81238-6

• Formation of p27-CDK complexes during the human mitotic cell cycle.

  PubMed · 1996

• The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression.

  Genes & Development · 1996 · 10.1101/gad.10.23.3065

• Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.

  Molecular and Cellular Biology · 1994 · 10.1128/mcb.14.11.7195

• Effects of Insulin on Vasoconstrictive Responses to Norepinephrine and Angiotensin II in Rabbit Femoral Artery and Vein

  Diabetes · 1988 · 10.2337/diab.37.8.1064

• Myogenic Hyperuricemia

  New England Journal of Medicine · 1987 · 10.1056/nejm198707093170203

Current projects

No projects listed.