Herbert Y. Meltzer

Research interests

Publications

• Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors

  Carolina Digital Repository (University of North Carolina at Chapel Hill) · 2019 · https://doi.org/10.17615/74zp-ze10

• Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology

  American Journal of Psychiatry · 2016 · https://doi.org/10.1176/appi.ajp.2016.16050503

• Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebo-controlled trial*

  Critical Care Medicine · 2010 · https://doi.org/10.1097/ccm.0b013e3181c58715

• A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia

  PLoS Genetics · 2009 · https://doi.org/10.1371/journal.pgen.1000373

• Suicide risk in schizophrenia: learning from the past to change the future

  Annals of General Psychiatry · 2007 · https://doi.org/10.1186/1744-859x-6-10

• Effectiveness of Clozapine Versus Olanzapine, Quetiapine, and Risperidone in Patients With Chronic Schizophrenia Who Did Not Respond to Prior Atypical Antipsychotic Treatment

  American Journal of Psychiatry · 2006 · https://doi.org/10.1176/ajp.2006.163.4.600

• Baseline Neurocognitive Deficits in the CATIE Schizophrenia Trial

  Neuropsychopharmacology · 2006 · https://doi.org/10.1038/sj.npp.1301072

• Prevalence of the metabolic syndrome in patients with schizophrenia: Baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III

  Schizophrenia Research · 2005 · https://doi.org/10.1016/j.schres.2005.07.014

• A meta-analysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia

  The International Journal of Neuropsychopharmacology · 2005 · https://doi.org/10.1017/s146114570500516x

• Cellular changes in the postmortem hippocampus in major depression

  Biological Psychiatry · 2004 · https://doi.org/10.1016/j.biopsych.2004.08.022

• Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain

  European Journal of Pharmacology · 2004 · https://doi.org/10.1016/j.ejphar.2004.04.028

• H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

  Neuropsychopharmacology · 2003 · https://doi.org/10.1038/sj.npp.1300027

• Serotonin receptors : their key role in drugs to treat schizophrenia

  Progress in Neuro-Psychopharmacology and Biological Psychiatry · 2003 · https://doi.org/10.1016/j.pnpbp.2003.09.010

• Clozapine Treatment for Suicidality in Schizophrenia International Suicide Prevention Trial (InterSePT)

  Archives of General Psychiatry · 2003 · https://doi.org/10.1001/archpsyc.60.1.82

• Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism

  Brain Research · 2002 · https://doi.org/10.1016/s0006-8993(02)03570-9

• 5‐HT2A and D2 receptor blockade increases cortical DA release via 5‐HT1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release

  Journal of Neurochemistry · 2001 · https://doi.org/10.1046/j.1471-4159.2001.00154.x

• Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

  Biological Psychiatry · 1999 · https://doi.org/10.1016/s0006-3223(99)00041-4

• Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

  Psychiatry Research · 1999 · https://doi.org/10.1016/s0165-1781(99)00014-1

• Treatment-Resistant Schizophrenia - The Role of Clozapine

  Current Medical Research and Opinion · 1997 · https://doi.org/10.1185/03007999709113338

• Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression

  Journal of Affective Disorders · 1995 · https://doi.org/10.1016/0165-0327(95)00028-l

• Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression

  Psychiatry Research · 1993 · https://doi.org/10.1016/0165-1781(93)90027-e

• Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

  Journal of Pharmacology and Experimental Therapeutics · 1989 · https://doi.org/10.1016/s0022-3565(25)20710-8

• Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia

  Psychopharmacology · 1989 · https://doi.org/10.1007/bf00442554

Current projects

No projects listed.