Jochen H. Lorch

Research interests

Publications

• Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck

  Clinical Cancer Research · 2021 · 10.1158/1078-0432.ccr-21-2635

• Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck

  Clinical Cancer Research · 2021 · 10.1158/1078-0432.ccr-21-2635

• A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma

  International Journal of Radiation Oncology*Biology*Physics · 2020 · 10.1016/j.ijrobp.2020.08.018

• Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma

  JAMA Oncology · 2020 · 10.1001/jamaoncol.2020.2955

• A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma

  International Journal of Radiation Oncology*Biology*Physics · 2020 · 10.1016/j.ijrobp.2020.08.018

• Efficacy of Selpercatinib in RET -Altered Thyroid Cancers

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2005651

• The Safety and Efficacy of Checkpoint Inhibitors in Transplant Recipients: A Case Series and Systematic Review of Literature

  The Oncologist · 2020 · 10.1634/theoncologist.2019-0659

• Genomic Correlates of Response to Everolimus in Aggressive Radioiodine-refractory Thyroid Cancer: A Phase II Study

  Clinical Cancer Research · 2018 · 10.1158/1078-0432.ccr-17-2297

• Updated efficacy of avelumab in patients with previously treated metastatic Merkel cell carcinoma after ≥1 year of follow-up: JAVELIN Merkel 200, a phase 2 clinical trial

  Journal for ImmunoTherapy of Cancer · 2018 · 10.1186/s40425-017-0310-x

• Frameshift events predict anti–PD-1/L1 response in head and neck cancer

  JCI Insight · 2018 · 10.1172/jci.insight.98811

• CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

  Cancer Discovery · 2017 · 10.1158/2159-8290.cd-17-0915

• Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck

  Oral Oncology · 2017 · 10.1016/j.oraloncology.2017.02.005

• Epstein‐Barr virus‐specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma

  Cancer · 2017 · 10.1002/cncr.30541

• Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

  Cancer Discovery · 2017 · 10.1158/2159-8290.cd-17-0833

• Epstein‐Barr virus‐specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma

  Cancer · 2017 · 10.1002/cncr.30541

• Defining an inflamed tumor immunophenotype in recurrent, metastatic squamous cell carcinoma of the head and neck

  Oral Oncology · 2017 · 10.1016/j.oraloncology.2017.02.005

• Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer

  British Journal of Cancer · 2016 · 10.1038/bjc.2016.166

• Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer

  British Journal of Cancer · 2016 · 10.1038/bjc.2016.166

• Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(16)30364-3

• Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus–Related Oropharyngeal Carcinoma

  JAMA Oncology · 2015 · 10.1001/jamaoncol.2015.2524

• Prognostic Implication of Persistent Human Papillomavirus Type 16 DNA Detection in Oral Rinses for Human Papillomavirus–Related Oropharyngeal Carcinoma

  JAMA Oncology · 2015 · 10.1001/jamaoncol.2015.2524

• Genomic Analysis of Metastatic Cutaneous Squamous Cell Carcinoma

  Clinical Cancer Research · 2015 · 10.1158/1078-0432.ccr-14-1773

• Response and Acquired Resistance to Everolimus in Anaplastic Thyroid Cancer

  New England Journal of Medicine · 2014 · 10.1056/nejmoa1403352

• Pilot study: Raman spectroscopy in differentiating premalignant and malignant oral lesions from normal mucosa and benign lesions in humans

  Head & Neck · 2014 · 10.1002/hed.23629

• Pilot study: Raman spectroscopy in differentiating premalignant and malignant oral lesions from normal mucosa and benign lesions in humans

  Head & Neck · 2014 · 10.1002/hed.23629

• Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial

  The Lancet Oncology · 2013 · 10.1016/s1470-2045(13)70011-1

• Trastuzumab for the Treatment of Salivary Duct Carcinoma

  The Oncologist · 2013 · 10.1634/theoncologist.2012-0369

• Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck: long-term results of the TAX 324 randomised phase 3 trial

  The Lancet Oncology · 2011 · 10.1016/s1470-2045(10)70279-5

• Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial

  Annals of Oncology · 2011 · 10.1093/annonc/mdr006

• Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer

  Molecular Cancer Research · 2010 · 10.1158/1541-7786.mcr-10-0162

• Autophagy Induction with RAD001 Enhances Chemosensitivity and Radiosensitivity through Met Inhibition in Papillary Thyroid Cancer

  Molecular Cancer Research · 2010 · 10.1158/1541-7786.mcr-10-0162

• Racial Survival Disparity in Head and Neck Cancer Results from Low Prevalence of Human Papillomavirus Infection in Black Oropharyngeal Cancer Patients

  Cancer Prevention Research · 2009 · 10.1158/1940-6207.capr-09-0149

• Epidermal Growth Factor Receptor Inhibition Promotes Desmosome Assembly and Strengthens Intercellular Adhesion in Squamous Cell Carcinoma Cells

  Journal of Biological Chemistry · 2004 · 10.1074/jbc.m405123200

Current projects

No projects listed.