Neil L. Kelleher

Research interests

Publications

• The emerging landscape of single-molecule protein sequencing technologies

  Nature Methods · 2021 · https://doi.org/10.1038/s41592-021-01143-1

• A computational framework to explore large-scale biosynthetic diversity

  Nature Chemical Biology · 2019 · https://doi.org/10.1038/s41589-019-0400-9

• Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

  Nature Methods · 2019 · https://doi.org/10.1038/s41592-019-0457-0

• How many human proteoforms are there?

  Nature Chemical Biology · 2018 · https://doi.org/10.1038/nchembio.2576

• Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

  Nature Medicine · 2017 · https://doi.org/10.1038/nm.4296

• Progress in Top-Down Proteomics and the Analysis of Proteoforms

  Annual Review of Analytical Chemistry · 2016 · https://doi.org/10.1146/annurev-anchem-071015-041550

• Loss of BAP1 function leads to EZH2-dependent transformation

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3947

• A roadmap for natural product discovery based on large-scale genomics and metabolomics

  Nature Chemical Biology · 2014 · https://doi.org/10.1038/nchembio.1659

• Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

  PLoS Genetics · 2014 · https://doi.org/10.1371/journal.pgen.1004566

• Top Down proteomics: Facts and perspectives

  Biochemical and Biophysical Research Communications · 2014 · https://doi.org/10.1016/j.bbrc.2014.02.041

• Top Down Proteomics

  Analytical Chemistry · 2013 · https://doi.org/10.1021/ac401484r

• Proteoform: a single term describing protein complexity

  Nature Methods · 2013 · https://doi.org/10.1038/nmeth.2369

• EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

  Cancer Cell · 2013 · https://doi.org/10.1016/j.ccr.2013.04.011

• Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation

  Journal of the American Chemical Society · 2013 · https://doi.org/10.1021/ja4029654

• Mapping intact protein isoforms in discovery mode using top-down proteomics

  Nature · 2011 · https://doi.org/10.1038/nature10575

• The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells

  Blood · 2010 · https://doi.org/10.1182/blood-2010-07-298349

• Precision proteomics: The case for high resolution and high mass accuracy

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0800788105

• Decoding protein modifications using top-down mass spectrometry

  Nature Methods · 2007 · https://doi.org/10.1038/nmeth1097

• A monovalent streptavidin with a single femtomolar biotin binding site

  Nature Methods · 2006 · https://doi.org/10.1038/nmeth861

• Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase

  Proceedings of the National Academy of Sciences · 2005 · https://doi.org/10.1073/pnas.0507705102

• Peer Reviewed: Top-Down Proteomics

  Analytical Chemistry · 2004 · https://doi.org/10.1021/ac0415657

• Electron Capture Dissociation for Structural Characterization of Multiply Charged Protein Cations

  Analytical Chemistry · 2000 · https://doi.org/10.1021/ac990811p

• Localization of Labile Posttranslational Modifications by Electron Capture Dissociation: The Case of γ-Carboxyglutamic Acid

  Analytical Chemistry · 1999 · https://doi.org/10.1021/ac990684x

• Top Down versus Bottom Up Protein Characterization by Tandem High-Resolution Mass Spectrometry

  Journal of the American Chemical Society · 1999 · https://doi.org/10.1021/ja973655h

• Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process

  Journal of the American Chemical Society · 1998 · https://doi.org/10.1021/ja973478k

• Attomole Protein Characterization by Capillary Electrophoresis-Mass Spectrometry

  Science · 1996 · https://doi.org/10.1126/science.273.5279.1199

Current projects

No projects listed.