Manu Jain

Research interests

Publications

• An integrated cell atlas of the lung in health and disease

  Nature Medicine · 2023 · https://doi.org/10.1038/s41591-023-02327-2

• Inhaled mRNA therapy for treatment of cystic fibrosis: Interim results of a randomized, double‐blind, placebo‐controlled phase 1/2 clinical study

  Journal of Cystic Fibrosis · 2023 · 10.1016/j.jcf.2023.04.008

• Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial

  The Lancet · 2019 · https://doi.org/10.1016/s0140-6736(19)32597-8

• A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF/M-CSFR signalling in monocyte-derived alveolar macrophages

  European Respiratory Journal · 2019 · 10.1183/13993003.00646-2019

• Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

  American Journal of Respiratory and Critical Care Medicine · 2018 · https://doi.org/10.1164/rccm.201712-2410oc

• Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

  The Journal of Experimental Medicine · 2017 · https://doi.org/10.1084/jem.20162152

• Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

  Infection Control and Hospital Epidemiology · 2014 · 10.1086/676882

• Mitochondrial Reactive Oxygen Species Regulate Transforming Growth Factor-β Signaling

  Journal of Biological Chemistry · 2012 · 10.1074/jbc.m112.431973

• Nuclear β-Catenin Is Increased in Systemic Sclerosis Pulmonary Fibrosis and Promotes Lung Fibroblast Migration and Proliferation

  American Journal of Respiratory Cell and Molecular Biology · 2011 · 10.1165/rcmb.2010-0113oc

• Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation

  Thorax · 2011 · 10.1136/thoraxjnl-2011-200393

• Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis

  Clinical Microbiology Reviews · 2011 · 10.1128/cmr.00036-10

• PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

  PLoS ONE · 2010 · 10.1371/journal.pone.0013778

• Beyond Mortality: Future Clinical Research in Acute Lung Injury

  American Journal of Respiratory and Critical Care Medicine · 2010 · https://doi.org/10.1164/rccm.201001-0024ws

• Type III Secretion Phenotypes of Pseudomonas aeruginosa Strains Change during Infection of Individuals with Cystic Fibrosis

  Journal of Clinical Microbiology · 2004 · 10.1128/jcm.42.11.5229-5237.2004

• Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa

  Microbiology · 2001 · 10.1099/00221287-147-10-2659

Current projects

No projects listed.