C. David James

Research interests

Publications

• A first-in-human phase 0 clinical study of RNA interference–based spherical nucleic acids in patients with recurrent glioblastoma

  Science Translational Medicine · 2021 · 10.1126/scitranslmed.abb3945

• An Overview of Meningiomas

  Future Oncology · 2018 · 10.2217/fon-2018-0006

• Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

  Nature Medicine · 2017 · 10.1038/nm.4296

• Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

  Nature Medicine · 2014 · 10.1038/nm.3716

• The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

  Genes & Development · 2013 · https://doi.org/10.1101/gad.217778.113

• Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

  Science · 2013 · https://doi.org/10.1126/science.1241328

• Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin

  Journal of Clinical Oncology · 2011 · 10.1200/jco.2010.33.8715

• An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

  Cancer Discovery · 2011 · 10.1158/2159-8290.cd-11-0102

• Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer

  Science · 2011 · 10.1126/science.1203619

• Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma

  Science Signaling · 2010 · 10.1126/scisignal.2001017

• A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

  Cancer Cell · 2010 · 10.1016/j.ccr.2009.12.049

• Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

  Cancer Research · 2010 · 10.1158/0008-5472.can-09-4559

• Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2009.12.020

• Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

  Neuro-Oncology · 2008 · 10.1215/15228517-2008-090

• miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

  BMC Medicine · 2008 · https://doi.org/10.1186/1741-7015-6-14

• Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma

  Clinical Cancer Research · 2008 · 10.1158/1078-0432.ccr-07-1719

• Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma

  Journal of Clinical Oncology · 2008 · 10.1200/jco.2008.18.9639

• Epidermal Growth Factor Receptor Variant III Status Defines Clinically Distinct Subtypes of Glioblastoma

  Journal of Clinical Oncology · 2007 · 10.1200/jco.2006.08.0705

• Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

  Neuro-Oncology · 2005 · 10.1215/s1152851704000821

• PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme

  JNCI Journal of the National Cancer Institute · 2001 · 10.1093/jnci/93.16.1246

• Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

  PubMed · 2000

• Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p.

  PubMed · 1994

• Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

  Proceedings of the National Academy of Sciences · 1992 · 10.1073/pnas.89.10.4309

• Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo.

  PubMed · 1991

• Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

  Proceedings of the National Academy of Sciences · 1990 · 10.1073/pnas.87.21.8602

Current projects

No projects listed.