Deyu Fang

Research interests

Publications

• Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2

  Nature Communications · 2022 · https://doi.org/10.1038/s41467-021-27893-2

• CRISPR screen in regulatory T cells reveals modulators of Foxp3

  Nature · 2020 · 10.1038/s41586-020-2246-4

• BDNF Val66Met polymorphism, life stress and depression: A meta-analysis of gene-environment interaction

  Journal of Affective Disorders · 2017 · 10.1016/j.jad.2017.10.024

• TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis

  Cancer Research · 2016 · 10.1158/0008-5472.can-15-1293

• IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation

  Nature Cell Biology · 2015 · 10.1038/ncb3266

• Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis

  Genes & Development · 2014 · 10.1101/gad.238246.114

• The Roles of SIRT1 in Cancer

  Genes & Cancer · 2013 · 10.1177/1947601912475079

• USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

  Cell Reports · 2013 · 10.1016/j.celrep.2013.11.029

• The structural basis of R-spondin recognition by LGR5 and RNF43

  Genes & Development · 2013 · 10.1101/gad.219915.113

• Toll‐like receptor‐mediated IRE1α activation as a therapeutic target for inflammatory arthritis

  The EMBO Journal · 2013 · 10.1038/emboj.2013.183

• USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

  Molecular Cell · 2012 · 10.1016/j.molcel.2012.03.024

• Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes

  Diabetologia · 2011 · 10.1007/s00125-011-2064-1

• Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

  Diabetes · 2011 · https://doi.org/10.2337/db11-0807

• The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

  Diabetes · 2010 · 10.2337/db09-1342

• Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

  Molecular Cell · 2009 · https://doi.org/10.1016/j.molcel.2009.04.029

• The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

  Journal of Clinical Investigation · 2009 · https://doi.org/10.1172/jci38902

• RLE-1, an E3 Ubiquitin Ligase, Regulates C. elegans Aging by Catalyzing DAF-16 Polyubiquitination

  Developmental Cell · 2007 · 10.1016/j.devcel.2006.12.002

• Jun Turnover Is Controlled Through JNK-Dependent Phosphorylation of the E3 Ligase Itch

  Science · 2004 · 10.1126/science.1099414

• Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes

  Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0404445101

• Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation

  Nature Immunology · 2002 · 10.1038/ni763

• The Tight Junction-specific Protein Occludin Is a Functional Target of the E3 Ubiquitin-protein Ligase Itch

  Journal of Biological Chemistry · 2002 · 10.1074/jbc.m111384200

• Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m010738200

• Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m008901200

• Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

  Nature Immunology · 2001 · 10.1038/ni0901-870

• Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase

  Journal of Biological Chemistry · 2000 · 10.1074/jbc.m007300200

Current projects

No projects listed.