Leonidas C. Platanias

Research interests

Publications

• Subtype-specific 3D genome alteration in acute myeloid leukaemia

  Nature · 2022 · https://doi.org/10.1038/s41586-022-05365-x

• Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways

  Frontiers in Immunology · 2020 · https://doi.org/10.3389/fimmu.2020.606456

• IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma

  Clinical Cancer Research · 2018 · https://doi.org/10.1158/1078-0432.ccr-17-3573

• Repurposing metformin for cancer treatment: current clinical studies

  Oncotarget · 2016 · https://doi.org/10.18632/oncotarget.8194

• AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

  Blood · 2013 · https://doi.org/10.1182/blood-2013-04-495366

• Role of the Akt pathway in mRNA translation of interferon-stimulated genes

  Proceedings of the National Academy of Sciences · 2008 · https://doi.org/10.1073/pnas.0710907105

• Mechanisms of type-I- and type-II-interferon-mediated signalling

  Nature reviews. Immunology · 2005 · https://doi.org/10.1038/nri1604

• Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling

  Molecular and Cellular Biology · 2005 · https://doi.org/10.1128/mcb.25.12.4853-4862.2005

• Genistein Inhibits p38 Map Kinase Activation, Matrix Metalloproteinase Type 2, and Cell Invasion in Human Prostate Epithelial Cells

  Cancer Research · 2005 · https://doi.org/10.1158/0008-5472.can-04-2807

• Interferons: mechanisms of action and clinical applications

  Current Opinion in Oncology · 2003 · https://doi.org/10.1097/00001622-200311000-00005

• Map kinase signaling pathways and hematologic malignancies

  Blood · 2003 · https://doi.org/10.1182/blood-2002-12-3647

• Protein Kinase C-δ (PKC-δ) Is Activated by Type I Interferons and Mediates Phosphorylation of Stat1 on Serine 727

  Journal of Biological Chemistry · 2002 · https://doi.org/10.1074/jbc.m109671200

• The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins

  Journal of Biological Chemistry · 2000 · https://doi.org/10.1074/jbc.m003170200

• Signaling pathways activated by interferons

  Experimental Hematology · 1999 · https://doi.org/10.1016/s0301-472x(99)00109-5

• Activation of the p38 Mitogen-activated Protein Kinase by Type I Interferons

  Journal of Biological Chemistry · 1999 · https://doi.org/10.1074/jbc.274.42.30127

• Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2.

  PubMed · 1998 · https://doi.org/10.1182/blood.v91.2.399

• Direct Association with and Dephosphorylation of Jak2 Kinase by the SH2-Domain-Containing Protein Tyrosine Phosphatase SHP-1

  Molecular and Cellular Biology · 1996 · https://doi.org/10.1128/mcb.16.12.6985

• Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase

  Journal of Biological Chemistry · 1995 · https://doi.org/10.1074/jbc.270.27.15938

• Studies of interferon as a regulator of hematopoietic cell proliferation.

  The Journal of Immunology · 1985 · https://doi.org/10.4049/jimmunol.135.4.2507

Current projects

No projects listed.