Gavin Ha

Research interests

Publications

• Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

  Cell · 2021 · https://doi.org/10.1016/j.cell.2021.03.009

• Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

  Nature Medicine · 2020 · https://doi.org/10.1038/s41591-020-0915-3

• Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

  Cell Reports · 2020 · 10.1016/j.celrep.2020.107669

• The evolutionary history of 2,658 cancers

  Nature · 2020 · https://doi.org/10.1038/s41586-019-1907-7

• Prostate cancer reactivates developmental epigenomic programs during metastatic progression

  Nature Genetics · 2020 · 10.1038/s41588-020-0664-8

• Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing

  Cell · 2018 · https://doi.org/10.1016/j.cell.2018.05.036

• Genetic and transcriptional evolution alters cancer cell line drug response

  Nature · 2018 · https://doi.org/10.1038/s41586-018-0409-3

• The Integrated Genomic Landscape of Thymic Epithelial Tumors

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.01.003

• Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes

  Nature Genetics · 2017 · 10.1038/ng.3849

• Patient-derived xenografts undergo mouse-specific tumor evolution

  Nature Genetics · 2017 · https://doi.org/10.1038/ng.3967

• Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

  Nature Communications · 2017 · https://doi.org/10.1038/s41467-017-00965-y

• Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

  Cancer Discovery · 2017 · 10.1158/2159-8290.cd-17-0395

• Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

  Nature Genetics · 2016 · 10.1038/ng.3573

• Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

  Cancer Discovery · 2016 · https://doi.org/10.1158/2159-8290.cd-16-0154

• TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

  Genome Research · 2014 · https://doi.org/10.1101/gr.180281.114

• PyClone: statistical inference of clonal population structure in cancer

  Nature Methods · 2014 · https://doi.org/10.1038/nmeth.2883

• Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

  Nature · 2014 · 10.1038/nature13952

• Distinct evolutionary trajectories of primary high‐grade serous ovarian cancers revealed through spatial mutational profiling

  The Journal of Pathology · 2013 · https://doi.org/10.1002/path.4230

• The clonal and mutational evolution spectrum of primary triple-negative breast cancers

  Nature · 2012 · 10.1038/nature10933

• DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer

  Genome biology · 2012 · 10.1186/gb-2012-13-12-r124

• The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

  Nature · 2012 · 10.1038/nature10983

• Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

  Genome Research · 2012 · 10.1101/gr.137570.112

• deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

  PLoS Computational Biology · 2011 · https://doi.org/10.1371/journal.pcbi.1001138

• Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

  New England Journal of Medicine · 2011 · https://doi.org/10.1056/nejmoa1102903

• ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

  New England Journal of Medicine · 2010 · 10.1056/nejmoa1008433

Current projects

No projects listed.