Charles M. Perou

Research interests

Publications

• A single-cell and spatially resolved atlas of human breast cancers

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00911-1

• Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update

  Journal of Clinical Oncology · 2020 · https://doi.org/10.1200/jco.19.02309

• Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

  Nature Medicine · 2018 · https://doi.org/10.1038/s41591-018-0009-7

• Proteogenomics connects somatic mutations to signalling in breast cancer

  Nature · 2016 · https://doi.org/10.1038/nature18003

• Progesterone receptor modulates ERα action in breast cancer

  Nature · 2015 · 10.1038/nature14583

• Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

  Cell · 2015 · https://doi.org/10.1016/j.cell.2015.09.033

• Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis

  The Lancet · 2014 · 10.1016/s0140-6736(13)62422-8

• Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

  Cell · 2014 · 10.1016/j.cell.2014.06.049

• The Somatic Genomic Landscape of Glioblastoma

  Cell · 2013 · https://doi.org/10.1016/j.cell.2013.09.034

• Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

  Cell Reports · 2013 · 10.1016/j.celrep.2013.08.022

• Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013

  Annals of Oncology · 2013 · 10.1093/annonc/mdt303

• Basal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival

  Breast Cancer Research and Treatment · 2011 · 10.1007/s10549-011-1846-y

• Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

  Breast Cancer Research · 2010 · 10.1186/bcr2635

• Genome remodelling in a basal-like breast cancer metastasis and xenograft

  Nature · 2010 · 10.1038/nature08989

• Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

  Cancer Cell · 2010 · https://doi.org/10.1016/j.ccr.2009.12.020

• A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer

  Clinical Cancer Research · 2010 · 10.1158/1078-0432.ccr-10-1282

• Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

  Cancer Cell · 2010 · 10.1016/j.ccr.2010.03.017

• MapSplice: Accurate mapping of RNA-seq reads for splice junction discovery

  Nucleic Acids Research · 2010 · 10.1093/nar/gkq622

• Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

  JNCI Journal of the National Cancer Institute · 2009 · 10.1093/jnci/djp082

• Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

  Journal of Clinical Oncology · 2009 · 10.1200/jco.2008.18.1370

• Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

  Cancer Research · 2009 · 10.1158/0008-5472.can-08-3441

• The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes

  Clinical Cancer Research · 2007 · 10.1158/1078-0432.ccr-06-1109

• Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study

  JAMA · 2006 · 10.1001/jama.295.21.2492

• The molecular portraits of breast tumors are conserved across microarray platforms

  BMC Genomics · 2006 · 10.1186/1471-2164-7-96

• Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

  Clinical Cancer Research · 2005 · 10.1158/1078-0432.ccr-04-2421

• A custom microarray platform for analysis of microRNA gene expression

  Nature Methods · 2004 · 10.1038/nmeth704

• Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma

  Clinical Cancer Research · 2004 · 10.1158/1078-0432.ccr-04-0220

• Repeated observation of breast tumor subtypes in independent gene expression data sets

  Proceedings of the National Academy of Sciences · 2003 · https://doi.org/10.1073/pnas.0932692100

• Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

  Molecular Biology of the Cell · 2002 · 10.1091/mbc.02-02-0030

• Expression of Cytokeratins 17 and 5 Identifies a Group of Breast Carcinomas with Poor Clinical Outcome

  American Journal Of Pathology · 2002 · 10.1016/s0002-9440(10)64476-8

• Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

  Proceedings of the National Academy of Sciences · 2001 · https://doi.org/10.1073/pnas.191367098

• Molecular portraits of human breast tumours

  Nature · 2000 · https://doi.org/10.1038/35021093

• Systematic variation in gene expression patterns in human cancer cell lines

  Nature Genetics · 2000 · 10.1038/73432

Current projects

No projects listed.