Yun Li

Research interests

Publications

• The Polygenic and Monogenic Basis of Blood Traits and Diseases

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.008

• Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.06.045

• DNA methylation GrimAge strongly predicts lifespan and healthspan

  Aging · 2019 · https://doi.org/10.18632/aging.101684

• DNA methylation-based estimator of telomere length

  Aging · 2019 · https://doi.org/10.18632/aging.102173

• Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations

  PLoS Genetics · 2019 · https://doi.org/10.1371/journal.pgen.1008500

• Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0516-6

• Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

  Aging · 2018 · https://doi.org/10.18632/aging.101508

• Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

  Nature Genetics · 2018 · 10.1038/s41588-018-0090-3

• An epigenetic biomarker of aging for lifespan and healthspan

  Aging · 2018 · https://doi.org/10.18632/aging.101414

• DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

  The American Journal of Human Genetics · 2017 · https://doi.org/10.1016/j.ajhg.2017.09.028

• Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

  Aging · 2017 · 10.18632/aging.101168

• Genetic loci associated with heart rate variability and their effects on cardiac disease risk

  Nature Communications · 2017 · https://doi.org/10.1038/ncomms15805

• A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome

  Cell Reports · 2016 · 10.1016/j.celrep.2016.10.061

• Acute kidney injury in China: a cross-sectional survey

  The Lancet · 2015 · https://doi.org/10.1016/s0140-6736(15)00344-x

• Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

  Human Molecular Genetics · 2015 · https://doi.org/10.1093/hmg/ddv161

• Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

  The American Journal of Human Genetics · 2014 · https://doi.org/10.1016/j.ajhg.2014.01.010

• An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People

  Science · 2012 · https://doi.org/10.1126/science.1217876

• Low-coverage sequencing: Implications for design of complex trait association studies

  Genome Research · 2011 · https://doi.org/10.1101/gr.117259.110

• Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.970

• The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

  Advances in Urology · 2011 · https://doi.org/10.1155/2012/530121

• METAL: fast and efficient meta-analysis of genomewide association scans

  Bioinformatics · 2010 · https://doi.org/10.1093/bioinformatics/btq340

• Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

  Nature Genetics · 2010 · https://doi.org/10.1038/ng.689

• A mouse knockout library for secreted and transmembrane proteins

  Nature Biotechnology · 2010 · https://doi.org/10.1038/nbt.1644

• MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

  Genetic Epidemiology · 2010 · https://doi.org/10.1002/gepi.20533

• Genotype Imputation

  Annual Review of Genomics and Human Genetics · 2009 · https://doi.org/10.1146/annurev.genom.9.081307.164242

• Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes

  The American Journal of Human Genetics · 2008 · https://doi.org/10.1016/j.ajhg.2008.09.012

• Common variants at 30 loci contribute to polygenic dyslipidemia

  Nature Genetics · 2008 · 10.1038/ng.291

• A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

  Science · 2007 · https://doi.org/10.1126/science.1142382

Current projects

No projects listed.