Thomas Vogl

Research interests

Publications

• Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

  Science Translational Medicine · 2020 · 10.1126/scitranslmed.abb5817

• Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

  Journal of Clinical Investigation · 2018 · 10.1172/jci89867

• Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia

  Cell stem cell · 2016 · 10.1016/j.stem.2016.08.021

• S100A8/A9: From basic science to clinical application

  Pharmacology & Therapeutics · 2016 · 10.1016/j.pharmthera.2016.07.015

• Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity

  Nature Communications · 2014 · 10.1038/ncomms5593

• Myeloid-Derived Suppressor Cells Regulate Growth of Multiple Myeloma by Inhibiting T Cells in Bone Marrow

  The Journal of Immunology · 2013 · 10.4049/jimmunol.1203373

• S100A8/A9 Proteins Mediate Neutrophilic Inflammation and Lung Pathology during Tuberculosis

  American Journal of Respiratory and Critical Care Medicine · 2013 · 10.1164/rccm.201304-0803oc

• Alarmins: awaiting a clinical response

  Journal of Clinical Investigation · 2012 · 10.1172/jci62423

• Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed Gut

  Cell Host & Microbe · 2012 · 10.1016/j.chom.2012.01.017

• Pro-Inflammatory S100A8 and S100A9 Proteins: Self-Assembly into Multifunctional Native and Amyloid Complexes

  International Journal of Molecular Sciences · 2012 · 10.3390/ijms13032893

• S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

  Molecular Cancer Research · 2011 · 10.1158/1541-7786.mcr-10-0394

• Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

  Nature Immunology · 2010 · 10.1038/ni.1919

• The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

  Nature Medicine · 2010 · https://doi.org/10.1038/nm.2150

• Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

  PLoS Biology · 2009 · 10.1371/journal.pbio.1000097

• The endogenous Toll–like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer

  Journal of Leukocyte Biology · 2009 · 10.1189/jlb.1008647

• Expression and Role of Myeloid-related Protein-14 in Clinical and Experimental Sepsis

  American Journal of Respiratory and Critical Care Medicine · 2009 · https://doi.org/10.1164/rccm.200810-1552oc

• RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis

  Carcinogenesis · 2008 · 10.1093/carcin/bgn188

• Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

  The Journal of Experimental Medicine · 2008 · https://doi.org/10.1084/jem.20080132

• Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

  Nature Medicine · 2007 · https://doi.org/10.1038/nm1638

• S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules

  Journal of Leukocyte Biology · 2006 · 10.1189/jlb.0306170

• Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells

  Blood · 2004 · 10.1182/blood-2004-07-2520

• MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes

  Blood · 2004 · 10.1182/blood-2004-02-0446

• Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules

  Trends in Immunology · 2003 · 10.1016/s1471-4906(03)00062-0

• The Ca2+-binding Proteins S100A8 and S100A9 Are Encoded by Novel Injury-regulated Genes

  Journal of Biological Chemistry · 2001 · 10.1074/jbc.m104871200

• Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis

  Arthritis & Rheumatism · 2000 · 10.1002/1529-0131(200003)43:3<628::aid-anr20>3.0.co;2-x

• S100A12 Is Expressed Exclusively by Granulocytes and Acts Independently from MRP8 and MRP14

  Journal of Biological Chemistry · 1999 · 10.1074/jbc.274.36.25291

Current projects

No projects listed.