Florent Ginhoux

Research interests

Publications

• Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

  Nature Communications · 2022 · https://doi.org/10.1038/s41467-022-29366-6

• Microglia states and nomenclature: A field at its crossroads

  Neuron · 2022 · https://doi.org/10.1016/j.neuron.2022.10.020

• A single-cell and spatially resolved atlas of human breast cancers

  Nature Genetics · 2021 · https://doi.org/10.1038/s41588-021-00911-1

• Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease

  Immunity · 2021 · https://doi.org/10.1016/j.immuni.2021.07.007

• Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19

  Cell · 2020 · 10.1016/j.cell.2020.08.002

• Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

  Cell · 2020 · https://doi.org/10.1016/j.cell.2020.08.040

• Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

  Cell · 2019 · 10.1016/j.cell.2019.05.054

• Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches

  Science · 2019 · 10.1126/science.aau0964

• Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

  Immunity · 2018 · https://doi.org/10.1016/j.immuni.2018.11.004

• Dimensionality reduction for visualizing single-cell data using UMAP

  Nature Biotechnology · 2018 · https://doi.org/10.1038/nbt.4314

• Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction

  Nature Immunology · 2018 · 10.1038/s41590-018-0272-2

• Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

  Immunity · 2016 · 10.1016/j.immuni.2016.03.012

• Tissue-Resident Macrophage Ontogeny and Homeostasis

  Immunity · 2016 · 10.1016/j.immuni.2016.02.024

• Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

  Immunity · 2016 · 10.1016/j.immuni.2016.08.015

• New insights into the multidimensional concept of macrophage ontogeny, activation and function

  Nature Immunology · 2015 · 10.1038/ni.3324

• C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

  Immunity · 2015 · 10.1016/j.immuni.2015.03.011

• Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

  Cell · 2015 · 10.1016/j.cell.2015.11.013

• Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

  Science · 2015 · https://doi.org/10.1126/science.aad1329

• Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

  Nature reviews. Immunology · 2014 · 10.1038/nri3712

• Monocytes and macrophages: developmental pathways and tissue homeostasis

  Nature reviews. Immunology · 2014 · 10.1038/nri3671

• IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses

  Immunity · 2013 · 10.1016/j.immuni.2013.04.011

• The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

  Science · 2013 · 10.1126/science.1240537

• Origin and differentiation of microglia

  Frontiers in Cellular Neuroscience · 2013 · 10.3389/fncel.2013.00045

• Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

  Immunity · 2013 · https://doi.org/10.1016/j.immuni.2013.04.004

• Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

  Science · 2010 · https://doi.org/10.1126/science.1194637

• Origin of the Lamina Propria Dendritic Cell Network

  Immunity · 2009 · 10.1016/j.immuni.2009.08.010

• Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells

  Nature reviews. Immunology · 2008 · 10.1038/nri2455

Current projects

No projects listed.