Patrick Tan

Research interests

Publications

• Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer

  Cancer Discovery · 2021 · https://doi.org/10.1158/2159-8290.cd-21-0683

• Genomic basis for RNA alterations in cancer

  Nature · 2020 · 10.1038/s41586-020-1970-0

• Enabling Technologies for Personalized and Precision Medicine

  Trends in biotechnology · 2020 · 10.1016/j.tibtech.2019.12.021

• Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment

  Oncogene · 2019 · 10.1038/s41388-019-0765-y

• Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

  Cancer Discovery · 2017 · https://doi.org/10.1158/2159-8290.cd-17-0368

• Meta-analysis of microsatellite instability in relation to clinicopathological characteristics and overall survival in gastric cancer

  British journal of surgery · 2017 · 10.1002/bjs.10663

• Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia

  Science Translational Medicine · 2017 · 10.1126/scitranslmed.aan6446

• Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer

  Cancer Cell · 2017 · 10.1016/j.ccell.2017.11.018

• Molecular classification of gastric cancer

  Annals of Oncology · 2016 · 10.1093/annonc/mdw040

• Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma

  Gastroenterology · 2015 · 10.1053/j.gastro.2015.05.059

• Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

  Nature Medicine · 2015 · https://doi.org/10.1038/nm.3850

• Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

  Clinical Cancer Research · 2014 · 10.1158/1078-0432.ccr-14-2481

• Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

  Science Translational Medicine · 2013 · 10.1126/scitranslmed.3006086

• Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

  Nature Genetics · 2013 · 10.1038/ng.2806

• Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil

  Gastroenterology · 2013 · 10.1053/j.gastro.2013.05.010

• Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

  Nature Genetics · 2012 · https://doi.org/10.1038/ng.2246

• A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

  Gut · 2012 · https://doi.org/10.1136/gutjnl-2011-301839

• Exome sequencing of liver fluke–associated cholangiocarcinoma

  Nature Genetics · 2012 · 10.1038/ng.2273

• A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

  Nature Medicine · 2012 · 10.1038/nm.2713

• Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy

  Gastroenterology · 2011 · 10.1053/j.gastro.2011.04.042

• Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

  Cancer Research · 2011 · 10.1158/0008-5472.can-10-3667

• Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

  Nature Medicine · 2010 · 10.1038/nm.2166

• Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target

  Journal of Biological Chemistry · 2008 · 10.1074/jbc.m707629200

• Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

  Science · 2008 · https://doi.org/10.1126/science.1165395

• "Fluorescent Timer": Protein That Changes Color with Time

  Science · 2000 · 10.1126/science.290.5496.1585

Current projects

No projects listed.