Lei Chen

Research interests

Publications

• Sintilimab Plus Chemotherapy for Unresectable Gastric or Gastroesophageal Junction Cancer

  JAMA · 2023 · https://doi.org/10.1001/jama.2023.19918

• Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial

  The Lancet · 2021 · https://doi.org/10.1016/s0140-6736(21)01123-5

• Stability issues of RT‐PCR testing of SARS‐CoV‐2 for hospitalized patients clinically diagnosed with COVID‐19

  Journal of Medical Virology · 2020 · https://doi.org/10.1002/jmv.25786

• COVID-19 in persons with haematological cancers

  Leukemia · 2020 · https://doi.org/10.1038/s41375-020-0836-7

• Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma

  New England Journal of Medicine · 2019 · https://doi.org/10.1056/nejmoa1905287

• Prognostic Value of Deep Learning PET/CT-Based Radiomics: Potential Role for Future Individual Induction Chemotherapy in Advanced Nasopharyngeal Carcinoma

  Clinical Cancer Research · 2019 · https://doi.org/10.1158/1078-0432.ccr-18-3065

• Concurrent chemoradiotherapy with/without induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: Long‐term results of phase 3 randomized controlled trial

  International Journal of Cancer · 2019 · https://doi.org/10.1002/ijc.32099

• Blockade of TIGIT/CD155 Signaling Reverses T-cell Exhaustion and Enhances Antitumor Capability in Head and Neck Squamous Cell Carcinoma

  Cancer Immunology Research · 2019 · https://doi.org/10.1158/2326-6066.cir-18-0725

• Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis

  BMJ · 2018 · https://doi.org/10.1136/bmj.k4226

• Proposed modifications and incorporation of plasma Epstein‐Barr virus DNA improve the TNM staging system for Epstein‐Barr virus‐related nasopharyngeal carcinoma

  Cancer · 2018 · https://doi.org/10.1002/cncr.31741

• Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial

  The Lancet Oncology · 2016 · https://doi.org/10.1016/s1470-2045(16)30410-7

• Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2015.63.5995

• Bevacizumab plus capecitabine and cisplatin in Chinese patients with inoperable locally advanced or metastatic gastric or gastroesophageal junction cancer: randomized, double-blind, phase III study (AVATAR study)

  Gastric Cancer · 2014 · https://doi.org/10.1007/s10120-014-0351-5

• Long noncoding RNA MALAT1 promotes brain metastasis by inducing epithelial-mesenchymal transition in lung cancer

  Journal of Neuro-Oncology · 2014 · https://doi.org/10.1007/s11060-014-1613-0

• Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis

  The Lancet Oncology · 2012 · https://doi.org/10.1016/s1470-2045(12)70102-x

• Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

  The Lancet Oncology · 2011 · https://doi.org/10.1016/s1470-2045(11)70184-x

• Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

  Science · 2011 · https://doi.org/10.1126/science.1209368

• Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial

  The Lancet Oncology · 2011 · https://doi.org/10.1016/s1470-2045(11)70320-5

• Genome remodelling in a basal-like breast cancer metastasis and xenograft

  Nature · 2010 · 10.1038/nature08989

• How Does Intensity-Modulated Radiotherapy Versus Conventional Two-Dimensional Radiotherapy Influence the Treatment Results in Nasopharyngeal Carcinoma Patients?

  International Journal of Radiation Oncology*Biology*Physics · 2010 · https://doi.org/10.1016/j.ijrobp.2010.03.024

• Safety and pharmacokinetics of novel selective vascular endothelial growth factor receptor-2 inhibitor YN968D1 in patients with advanced malignancies

  BMC Cancer · 2010 · https://doi.org/10.1186/1471-2407-10-529

• Re-Evaluation of 6th Edition of AJCC Staging System for Nasopharyngeal Carcinoma and Proposed Improvement Based on Magnetic Resonance Imaging

  International Journal of Radiation Oncology*Biology*Physics · 2009 · https://doi.org/10.1016/j.ijrobp.2008.07.062

• Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant

  Cancer Research · 2006 · https://doi.org/10.1158/0008-5472.can-06-1666

• Angiosarcoma of the breast

  Cancer · 2005 · https://doi.org/10.1002/cncr.21531

• Robust and fast similarity search for moving object trajectories

  Journal · 2005 · https://doi.org/10.1145/1066157.1066213

Current projects

No projects listed.