Rupert Handgretinger

Research interests

Publications

• CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

  New England Journal of Medicine · 2020 · https://doi.org/10.1056/nejmoa2031054

• Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia

  Cancer Cell · 2018 · https://doi.org/10.1016/j.ccell.2018.03.021

• The European Society for Blood and Marrow Transplantation (EBMT) Consensus Guidelines for the Detection and Treatment of Donor-specific Anti-HLA Antibodies (DSA) in Haploidentical Hematopoietic Cell Transplantation

  Bone Marrow Transplantation · 2018 · https://doi.org/10.1038/s41409-017-0062-8

• Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

  Blood · 2017 · 10.1182/blood-2017-04-779769

• Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia

  Journal of Clinical Oncology · 2016 · https://doi.org/10.1200/jco.2016.67.3301

• HLA-haploidentical stem cell transplantation after removal of αβ+ T and B cells in children with nonmalignant disorders

  Blood · 2014 · 10.1182/blood-2014-03-563817

• T-helper-1-cell cytokines drive cancer into senescence

  Nature · 2013 · 10.1038/nature11824

• Adoptive Transfer of Epstein-Barr Virus (EBV) Nuclear Antigen 1–Specific T Cells As Treatment for EBV Reactivation and Lymphoproliferative Disorders After Allogeneic Stem-Cell Transplantation

  Journal of Clinical Oncology · 2012 · https://doi.org/10.1200/jco.2011.39.8495

• Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

  Nature Biotechnology · 2011 · 10.1038/nbt.1733

• Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells

  Blood · 2010 · 10.1182/blood-2010-02-270777

• Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation

  Blood · 2010 · https://doi.org/10.1182/blood-2010-01-262089

• Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

  BMC Cell Biology · 2010 · 10.1186/1471-2121-11-11

• Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation

  New England Journal of Medicine · 2009 · https://doi.org/10.1056/nejmoa0900386

• Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group

  Blood · 2009 · https://doi.org/10.1182/blood-2009-03-207001

• Prognostic Value of Minimal Residual Disease Quantification Before Allogeneic Stem-Cell Transplantation in Relapsed Childhood Acute Lymphoblastic Leukemia: The ALL-REZ BFM Study Group

  Journal of Clinical Oncology · 2008 · 10.1200/jco.2008.17.6065

• Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM

  Cytotherapy · 2006 · https://doi.org/10.1080/14653240600920782

• Safe adoptive transfer of virus‐specific T‐cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation

  British Journal of Haematology · 2006 · https://doi.org/10.1111/j.1365-2141.2006.06108.x

• Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

  The Journal of Immunology · 2005 · https://doi.org/10.4049/jimmunol.174.10.6477

• Determinants of Antileukemia Effects of Allogeneic NK Cells

  The Journal of Immunology · 2004 · https://doi.org/10.4049/jimmunol.172.1.644

• Increasing Mixed Chimerism Is an Important Prognostic Factor for Unfavorable Outcome in Children With Acute Lymphoblastic Leukemia After Allogeneic Stem-Cell Transplantation: Possible Role For Pre-Emptive Immunotherapy?

  Journal of Clinical Oncology · 2004 · 10.1200/jco.2004.05.198

• Megadose transplantation of purified peripheral blood CD34+progenitor cells from HLA-mismatched parental donors in children

  Bone Marrow Transplantation · 2001 · https://doi.org/10.1038/sj.bmt.1702996

• Constitutional Mutations of the hSNF5/INI1 Gene Predispose to a Variety of Cancers

  The American Journal of Human Genetics · 1999 · 10.1086/302639

• Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

  Nature · 1998 · https://doi.org/10.1038/28212

Current projects

No projects listed.