John B. Holcomb

Research interests

Publications

• Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

  Journal of the American College of Surgeons · 2017 · https://doi.org/10.1016/j.jamcollsurg.2017.05.012

• Traumatic Endotheliopathy

  Annals of Surgery · 2016 · https://doi.org/10.1097/sla.0000000000001751

• The AAST prospective Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) registry

  The Journal of Trauma: Injury, Infection, and Critical Care · 2016 · 10.1097/ta.0000000000001079

• Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma

  The Journal of Trauma: Injury, Infection, and Critical Care · 2016 · https://doi.org/10.1097/ta.0000000000001304

• Damage control resuscitation in patients with severe traumatic hemorrhage

  The Journal of Trauma: Injury, Infection, and Critical Care · 2016 · 10.1097/ta.0000000000001333

• Clinical Practice Guidelines From the AABB

  JAMA · 2016 · https://doi.org/10.1001/jama.2016.9185

• Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma

  JAMA · 2015 · https://doi.org/10.1001/jama.2015.12

• The Effect of a Golden Hour Policy on the Morbidity and Mortality of Combat Casualties

  JAMA Surgery · 2015 · 10.1001/jamasurg.2015.3104

• Endothelial glycocalyx shedding and vascular permeability in severely injured trauma patients

  Journal of Translational Medicine · 2015 · https://doi.org/10.1186/s12967-015-0481-5

• How I treat patients with massive hemorrhage

  Blood · 2014 · https://doi.org/10.1182/blood-2014-05-575340

• A clinical series of resuscitative endovascular balloon occlusion of the aorta for hemorrhage control and resuscitation

  The Journal of Trauma: Injury, Infection, and Critical Care · 2013 · 10.1097/ta.0b013e31829e5416

• Red Blood Cell Transfusion: A Clinical Practice Guideline From the AABB*

  Annals of Internal Medicine · 2012 · https://doi.org/10.7326/0003-4819-157-1-201206190-00429

• The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study

  JAMA Surgery · 2012 · 10.1001/2013.jamasurg.387

• Death on the battlefield (2001–2011)

  The Journal of Trauma: Injury, Infection, and Critical Care · 2012 · https://doi.org/10.1097/ta.0b013e3182755dcc

• Plasma Restoration of Endothelial Glycocalyx in a Rodent Model of Hemorrhagic Shock

  Anesthesia & Analgesia · 2011 · 10.1213/ane.0b013e318210385c

• Damage Control Resuscitation Is Associated With a Reduction in Resuscitation Volumes and Improvement in Survival in 390 Damage Control Laparotomy Patients

  Annals of Surgery · 2011 · 10.1097/sla.0b013e318230089e

• Results of the CONTROL Trial: Efficacy and Safety of Recombinant Activated Factor VII in the Management of Refractory Traumatic Hemorrhage

  The Journal of Trauma: Injury, Infection, and Critical Care · 2010 · https://doi.org/10.1097/ta.0b013e3181edf36e

• Warm Fresh Whole Blood Is Independently Associated With Improved Survival for Patients With Combat-Related Traumatic Injuries

  The Journal of Trauma: Injury, Infection, and Critical Care · 2009 · 10.1097/ta.0b013e31819d85fb

• The Ratio of Fibrinogen to Red Cells Transfused Affects Survival in Casualties Receiving Massive Transfusions at an Army Combat Support Hospital

  The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · 10.1097/ta.0b013e318160a57b

• The Coagulopathy of Trauma: A Review of Mechanisms

  The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · https://doi.org/10.1097/ta.0b013e3181877a9c

• Combat Wounds in Operation Iraqi Freedom and Operation Enduring Freedom

  The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · 10.1097/ta.0b013e318163b875

• Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients

  Annals of Surgery · 2008 · 10.1097/sla.0b013e318185a9ad

• Survival With Emergency Tourniquet Use to Stop Bleeding in Major Limb Trauma

  Annals of Surgery · 2008 · 10.1097/sla.0b013e31818842ba

• Injury Severity and Causes of Death From Operation Iraqi Freedom and Operation Enduring Freedom: 2003–2004 Versus 2006

  The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · 10.1097/ta.0b013e318160b9fb

• Prehospital Tourniquet Use in Operation Iraqi Freedom: Effect on Hemorrhage Control and Outcomes

  The Journal of Trauma: Injury, Infection, and Critical Care · 2008 · 10.1097/ta.0b013e318160937e

• Fresh Frozen Plasma Should be Given Earlier to Patients Requiring Massive Transfusion

  The Journal of Trauma: Injury, Infection, and Critical Care · 2007 · 10.1097/01.ta.0000250497.08101.8b

• The Ratio of Blood Products Transfused Affects Mortality in Patients Receiving Massive Transfusions at a Combat Support Hospital

  The Journal of Trauma: Injury, Infection, and Critical Care · 2007 · https://doi.org/10.1097/ta.0b013e3181271ba3

• Causes of Death in U.S. Special Operations Forces in the Global War on Terrorism

  Annals of Surgery · 2007 · 10.1097/01.sla.0000259433.03754.98

• Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma

  The Journal of Trauma: Injury, Infection, and Critical Care · 2007 · https://doi.org/10.1097/ta.0b013e3180324124

• A Special Report on the Chitosan-based Hemostatic Dressing: Experience in Current Combat Operations

  The Journal of Trauma: Injury, Infection, and Critical Care · 2006 · 10.1097/01.ta.0000199392.91772.44

• United States Army Rangers in Somalia: An Analysis of Combat Casualties on an Urban Battlefield

  · 2000 · 10.1097/00005373-200009000-00021

Current projects

No projects listed.