Matthew Cook

Research interests

Publications

• TLR7 gain-of-function genetic variation causes human lupus

  Nature · 2022 · 10.1038/s41586-022-04642-z

• Fast-classifying, high-accuracy spiking deep networks through weight and threshold balancing

  Journal · 2015 · https://doi.org/10.1109/ijcnn.2015.7280696

• Unsupervised learning of digit recognition using spike-timing-dependent plasticity

  Frontiers in Computational Neuroscience · 2015 · https://doi.org/10.3389/fncom.2015.00099

• Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

  Immunity · 2013 · 10.1016/j.immuni.2013.09.007

• Updated assessment of the prevalence, spectrum and case definition of autoimmune disease

  Autoimmunity Reviews · 2012 · 10.1016/j.autrev.2012.02.001

• Functional STAT3 deficiency compromises the generation of human T follicular helper cells

  Blood · 2012 · 10.1182/blood-2011-11-392985

• IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells

  The Journal of Experimental Medicine · 2010 · 10.1084/jem.20100064

• B cell–intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

  The Journal of Experimental Medicine · 2010 · 10.1084/jem.20091706

• Follicular helper T cells are required for systemic autoimmunity

  The Journal of Experimental Medicine · 2009 · 10.1084/jem.20081886

• Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

  Arthritis & Rheumatism · 2009 · 10.1002/art.25032

• Dysregulation of germinal centres in autoimmune disease

  Nature reviews. Immunology · 2009 · 10.1038/nri2637

• Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

  The Journal of Experimental Medicine · 2008 · 10.1084/jem.20080218

• Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

  PLoS Medicine · 2008 · https://doi.org/10.1371/journal.pmed.0050054

• Computation with finite stochastic chemical reaction networks

  Natural Computing · 2008 · 10.1007/s11047-008-9067-y

• A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity

  Nature · 2005 · https://doi.org/10.1038/nature03555

• Universality in Elementary Cellular Automata

  Complex Systems · 2004 · https://doi.org/10.25088/complexsystems.15.1.1

• Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis

  Immunity · 2003 · 10.1016/s1074-7613(03)00141-9

• Extrafollicular antibody responses

  Immunological Reviews · 2003 · 10.1034/j.1600-065x.2003.00058.x

• Stress reactivity of the brain noradrenergic system in three rat strains differing in their neuroendocrine and behavioral responses to stress: implications for susceptibility to stress-related neuropsychiatric disorders

  Neuroscience · 2002 · 10.1016/s0306-4522(02)00364-0

• Germinal Centers without T Cells

  The Journal of Experimental Medicine · 2000 · 10.1084/jem.191.3.485

• Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

  European Journal of Immunology · 1997 · 10.1002/eji.1830271020

• The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

  The Journal of Experimental Medicine · 1996 · 10.1084/jem.183.5.2313

• Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.

  Genes & Development · 1991 · 10.1101/gad.5.11.2048

• ROLE OF GENETIC VARIATION AT THE FIBRINOGEN LOCUS IN DETERMINATION OF PLASMA FIBRINOGEN CONCENTRATIONS

  The Lancet · 1987 · 10.1016/s0140-6736(87)92205-7

• The Preparation of Chenodeoxycholic Acid and Its Glycine and Taurine Conjugates.

  Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry · 1963 · 10.3891/acta.chem.scand.17-0173

Current projects

No projects listed.