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Jeroen den Hertog

Researcher Next ID · RN-021030

Researcher · Biochemistry, Genetics and Molecular Biology

Leiden University

Leiden, Luxembourg

Not currently recruitingFunding unknown
Works count
198
Citation count
8,223
H-index
53
i10-index
118

Research interests

Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Protein Tyrosine Phosphatases
Galectins and Cancer Biology
Zebrafish Biomedical Research Applications
RNA modifications and cancer
PI3K/AKT/mTOR signaling in cancer

Publications

  • Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

    Acta Neuropathologica · 2016 · 10.1007/s00401-016-1575-8

  • A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality

    Nature Communications · 2013 · 10.1038/ncomms3754

  • Protein tyrosine phosphatases in health and disease

    FEBS Journal · 2012 · 10.1111/febs.12000

  • In-depth Qualitative and Quantitative Profiling of Tyrosine Phosphorylation Using a Combination of Phosphopeptide Immunoaffinity Purification and Stable Isotope Dimethyl Labeling

    Molecular & Cellular Proteomics · 2009 · 10.1074/mcp.m900291-mcp200

  • Protein tyrosine phosphatases: regulatory mechanisms

    FEBS Journal · 2008 · 10.1111/j.1742-4658.2008.06247.x

  • Laminin-α4 and Integrin-Linked Kinase Mutations Cause Human Cardiomyopathy Via Simultaneous Defects in Cardiomyocytes and Endothelial Cells

    Circulation · 2007 · 10.1161/circulationaha.107.689984

  • RPTPα is essential for NCAM-mediated p59fyn activation and neurite elongation

    The Journal of Cell Biology · 2004 · 10.1083/jcb.200405073

  • Redox regulation of protein-tyrosine phosphatases

    Archives of Biochemistry and Biophysics · 2004 · 10.1016/j.abb.2004.05.024

  • Differential Oxidation of Protein-tyrosine Phosphatases

    Journal of Biological Chemistry · 2004 · 10.1074/jbc.m412424200

  • Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

    Proceedings of the National Academy of Sciences · 2004 · 10.1073/pnas.0304403101

  • Receptor-Like Protein Tyrosine Phosphatase α Homodimerizes on the Cell Surface

    Molecular and Cellular Biology · 2000 · 10.1128/mcb.20.16.5917-5929.2000

  • Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-α

    Nature · 1999 · 10.1038/44170

  • The effect of elevated CO2 on the chemical composition and construction costs of leaves of 27 C3 species

    Plant Cell & Environment · 1997 · https://doi.org/10.1046/j.1365-3040.1997.d01-84.x

  • Structural basis for inhibition of receptor protein-tyrosine phosphatase-α by dimerization

    Nature · 1996 · https://doi.org/10.1038/382555a0

  • Phosphorylation of receptor protein‐tyrosine phosphatase alpha on Tyr789, a binding site for the SH3‐SH2‐SH3 adaptor protein GRB‐2 in vivo.

    The EMBO Journal · 1994 · 10.1002/j.1460-2075.1994.tb06601.x

  • Receptor protein tyrosine phosphatase alpha activates pp60c‐src and is involved in neuronal differentiation.

    The EMBO Journal · 1993 · https://doi.org/10.1002/j.1460-2075.1993.tb06057.x

  • Root growth and functioning under atmospheric CO2 enrichment

    Plant Ecology · 1993 · 10.1007/bf00048147

  • Multiple and cooperative phosphorylation events regulate the CREM activator function.

    The EMBO Journal · 1993 · 10.1002/j.1460-2075.1993.tb06068.x

  • Epidermal growth factor activates calcium channels by phospholipase A25-lipoxygenase-mediated leukotriene C4 production

    Cell · 1992 · https://doi.org/10.1016/0092-8674(92)90410-e

Current projects

    No projects listed.