Steve Horvath

Research interests

Publications

• Biomarkers of aging for the identification and evaluation of longevity interventions

  Cell · 2023 · https://doi.org/10.1016/j.cell.2023.08.003

• DNA methylation aging clocks: challenges and recommendations

  Genome biology · 2019 · https://doi.org/10.1186/s13059-019-1824-y

• DNA methylation GrimAge strongly predicts lifespan and healthspan

  Aging · 2019 · https://doi.org/10.18632/aging.101684

• Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

  Science · 2018 · 10.1126/science.aad6469

• Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies

  Aging · 2018 · https://doi.org/10.18632/aging.101508

• An epigenetic biomarker of aging for lifespan and healthspan

  Aging · 2018 · https://doi.org/10.18632/aging.101414

• DNA methylation-based biomarkers and the epigenetic clock theory of ageing

  Nature Reviews Genetics · 2018 · 10.1038/s41576-018-0004-3

• Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

  Aging · 2017 · 10.18632/aging.101168

• DNA methylation-based measures of biological age: meta-analysis predicting time to death

  Aging · 2016 · 10.18632/aging.101020

• DNA methylation age of blood predicts all-cause mortality in later life

  Genome biology · 2015 · 10.1186/s13059-015-0584-6

• DNA methylation age of human tissues and cell types

  Genome biology · 2013 · https://doi.org/10.1186/gb-2013-14-10-r115

• Integrative Functional Genomic Analyses Implicate Specific Molecular Pathways and Circuits in Autism

  Cell · 2013 · 10.1016/j.cell.2013.10.031

• Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing

  Nature · 2013 · 10.1038/nature12364

• Fast R Functions for Robust Correlations and Hierarchical Clustering.

  PubMed · 2012

• An anatomically comprehensive atlas of the adult human brain transcriptome

  Nature · 2012 · https://doi.org/10.1038/nature11405

• Fast R Functions for Robust Correlations and Hierarchical Clustering

  Journal of Statistical Software · 2012 · 10.18637/jss.v046.i11

• Is My Network Module Preserved and Reproducible?

  PLoS Computational Biology · 2011 · 10.1371/journal.pcbi.1001057

• Transcriptomic analysis of autistic brain reveals convergent molecular pathology

  Nature · 2011 · 10.1038/nature10110

• Epigenetic Predictor of Age

  PLoS ONE · 2011 · 10.1371/journal.pone.0014821

• WGCNA: an R package for weighted correlation network analysis

  BMC Bioinformatics · 2008 · https://doi.org/10.1186/1471-2105-9-559

• Geometric Interpretation of Gene Coexpression Network Analysis

  PLoS Computational Biology · 2008 · 10.1371/journal.pcbi.1000117

• Variations in DNA elucidate molecular networks that cause disease

  Nature · 2008 · 10.1038/nature06757

• Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R

  Bioinformatics · 2007 · 10.1093/bioinformatics/btm563

• Eigengene networks for studying the relationships between co-expression modules

  BMC Systems Biology · 2007 · 10.1186/1752-0509-1-54

• A General Framework for Weighted Gene Co-Expression Network Analysis

  Statistical Applications in Genetics and Molecular Biology · 2005 · https://doi.org/10.2202/1544-6115.1128

• Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

  New England Journal of Medicine · 2005 · 10.1056/nejmoa051918

• Global histone modification patterns predict risk of prostate cancer recurrence

  Nature · 2005 · 10.1038/nature03672

Current projects

No projects listed.