Sebastiaan Engelborghs

Research interests

Publications

• Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum

  JAMA Neurology · 2022 · https://doi.org/10.1001/jamaneurol.2021.5216

• Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0495-7

• Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

  Nature Genetics · 2019 · https://doi.org/10.1038/s41588-019-0358-2

• Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry

  The World Journal of Biological Psychiatry · 2017 · 10.1080/15622975.2017.1375556

• Consensus guidelines for lumbar puncture in patients with neurological diseases

  Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · 2017 · https://doi.org/10.1016/j.dadm.2017.04.007

• Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia

  JAMA Psychiatry · 2017 · https://doi.org/10.1001/jamapsychiatry.2017.3391

• sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

  EMBO Molecular Medicine · 2016 · 10.15252/emmm.201506123

• A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer’s disease

  Acta Neuropathologica · 2016 · https://doi.org/10.1007/s00401-016-1566-9

• Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study

  Alzheimer s & Dementia · 2015 · https://doi.org/10.1016/j.jalz.2015.08.003

• A Practical Guide to Immunoassay Method Validation

  Frontiers in Neurology · 2015 · 10.3389/fneur.2015.00179

• Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

  JAMA · 2015 · https://doi.org/10.1001/jama.2015.4668

• Prevalence and prognosis of Alzheimer’s disease at the mild cognitive impairment stage

  Brain · 2015 · https://doi.org/10.1093/brain/awv029

• TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-013-1239-x

• TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

  Science Translational Medicine · 2014 · https://doi.org/10.1126/scitranslmed.3009093

• Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration

  Acta Neuropathologica · 2014 · https://doi.org/10.1007/s00401-014-1298-7

• Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

  The Lancet Neurology · 2014 · https://doi.org/10.1016/s1474-4422(14)70090-0

• A Multicenter Study of Glucocerebrosidase Mutations in Dementia With Lewy Bodies

  JAMA Neurology · 2013 · 10.1001/jamaneurol.2013.1925

• Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

  Molecular Psychiatry · 2013 · 10.1038/mp.2013.1

• CSF biomarker variability in the Alzheimer's Association quality control program

  Alzheimer s & Dementia · 2013 · 10.1016/j.jalz.2013.01.010

• The genetics and neuropathology of frontotemporal lobar degeneration

  Acta Neuropathologica · 2012 · 10.1007/s00401-012-1029-x

• A Pan‐ E uropean Study of the C9orf72 Repeat Associated with FTLD : Geographic Prevalence, Genomic Instability, and Intermediate Repeats

  Human Mutation · 2012 · https://doi.org/10.1002/humu.22244

• A Pan‐ E uropean Study of the C9orf72 Repeat Associated with FTLD : Geographic Prevalence, Genomic Instability, and Intermediate Repeats

  Human Mutation · 2012 · https://doi.org/10.1002/humu.22244

• A Pan‐ E uropean Study of the C9orf72 Repeat Associated with FTLD : Geographic Prevalence, Genomic Instability, and Intermediate Repeats

  Human Mutation · 2012 · https://doi.org/10.1002/humu.22244

• Recommendations to Standardize Preanalytical Confounding Factors in Alzheimer’s and Parkinson’s Disease Cerebrospinal Fluid Biomarkers: An Update

  Biomarkers in Medicine · 2012 · 10.2217/bmm.12.46

• Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

  Nature Genetics · 2011 · https://doi.org/10.1038/ng.803

• A C9orf72 promoter repeat expansion in a Flanders-Belgian cohort with disorders of the frontotemporal lobar degeneration-amyotrophic lateral sclerosis spectrum: a gene identification study

  The Lancet Neurology · 2011 · https://doi.org/10.1016/s1474-4422(11)70261-7

• Standardization of preanalytical aspects of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative

  Alzheimer s & Dementia · 2011 · 10.1016/j.jalz.2011.07.004

• APOE and Alzheimer disease: a major gene with semi-dominant inheritance

  Molecular Psychiatry · 2011 · 10.1038/mp.2011.52

• Monitoring of Physical Activity After Stroke: A Systematic Review of Accelerometry-Based Measures

  Archives of Physical Medicine and Rehabilitation · 2010 · 10.1016/j.apmr.2009.10.025

• FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration

  Acta Neuropathologica · 2010 · https://doi.org/10.1007/s00401-010-0698-6

• Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.439

• Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

  Nature Genetics · 2009 · https://doi.org/10.1038/ng.440

• Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

  Nature · 2006 · 10.1038/nature05017

• The Lateralized Linguistic Cerebellum: A Review and a New Hypothesis

  Brain and Language · 2001 · 10.1006/brln.2001.2569

Current projects

No projects listed.